چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | فاطمه صلاح پور انرجان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 89682 |
| عنوان فارسی مقاله | نانوشیمی-ایمونوتراپی برای گلیوبلاستوما: نانوذرات کیتوزان هدفمند شده با دو لیگاند حاوی سیکلوفسفامید برای فعال سازی سیستم ایمنی در مدل های ارتوتوپیک موش صحرایی |
| عنوان لاتین مقاله | Nano-Chemo-Immunotherapy for Glioblastoma: Cyclophosphamide-Loaded Dual-Targeted Chitosan Nano particles for Immune Activation in Orthotopic Rat Models |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | Royan International Hybrid Twin Congress |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tehran |
| سال انتشار/ ارائه شمسی | 1404 |
| سال انتشار/ارائه میلادی | 2025 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1404/06/12 الی 1404/06/14 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://royancongress.com/index |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه صلاح پور انرجان | اول |
| امیر ضارب کهن | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Glioblastoma (GBM) is characterized by an immunosuppressive tumor microenvironment (TME) that limits the efficacy of current therapies. Conventional chemotherapy alone fails to elicit a durable immune response. This study investigates a novel nano-chemo-immunotherapeutic strategy using cyclophosphamide (CP)-loaded chitosan nanoparticles (CSNPs) modified with D8 and RI-VAP peptides to induce immunogenic cell death (ICD), promote immune activation, and reprogram the TME of GBM from 'cold' to 'hot' state. Materials and Methods: CP was encapsulated into CSNPs functionalized with D8 and RI-VAP peptides. CSNPs were characterized by DLS, SEM, and zeta potential. HMGB1 release was measured as a marker of ICD by western blot. Immune activation was assessed by dendritic cells (DC) maturation (CD80+, CD86⁺, CD11c⁺) and T-cell infiltration (CD4⁺, CD8⁺) using immunofluorescence. Results: CP-loaded dual-targeted CSNPs effectively induced ICD, with significant HMGB1 release. Enhanced DC maturation and increased infiltration of CD8+ and CD4+ T cells were observed in tumor tissue, indicating robust immune activation. Preliminary survival data suggest therapeutic benefit in orthotopic C6 glioma rat model. Conclusion: This nano-chemo-immunotherapy approach shows promising potential for GBM treatment by combining targeted drug delivery with immune stimulation. Preliminary in vivo findings suggest that the dual-targeted system not only penetrates brain barriers but also transforms the immunologically “cold” glioma tumor microenvironment into a “hot” one, thereby enhancing antitumor immunity. Keywords: Glioblastoma; Chitosan Nanoparticles; Blood-Brain Barrier (BBB); Nano-Chemo-Immunotherapy; Immunosuppressive Tumor Microenvironment |
| کلمات کلیدی | Glioblastoma; Chitosan Nanoparticles; Blood-Brain Barrier (BBB); Nano-Chemo-Immunotherapy; Immunosuppressive Tumor Microenvironment |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 01 Salahpour oral.jpg | 1404/11/19 | 1030015 | دانلود |
| 02 Salahpour oral.jpg | 1404/11/19 | 3805619 | دانلود |
| OS-13-Salahpour.pdf | 1404/11/19 | 127421 | دانلود |
