چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرزانه صادقی | دوم |
| عفت علیزاده | سوم |
| صفر فرج نیا | چهارم |
| مهناز صادقی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | HCC,Wnt Signaling Pathway, Wnt inhibitors |
| خلاصه مقاله | The inhibition of the Wnt signaling pathway has been identified as a promising target in the ongoing effort to enhance antitumor therapies, especially in hepatocellular carcinoma. The way that Wnt signaling is altered in human tumors suggests a way to inhibit its activity, which could affect patient survival and clinical results. Inhibitors of Wnt signaling are being thoroughly studied because tumors frequently have mutations or epigenetically changed Wnt pathways, which encourage their activation. It has been demonstrated that both in vitro and in vivo tumor growth is inhibited by knocking down particular Wnt pathway components. Consequently, comparable outcomes are anticipated from the use of Wnt inhibitors. Over the past few decades, compounds that function as inhibitors at particular molecular levels of the pathway have been found and described. Considering all of these, inhibition of the Wnt signalling pathway has the potential to develop future therapies. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| r_18_251001141525.pdf | 1404/10/20 | 339422 | دانلود |
| 22.pdf | 1404/10/20 | 1262657 | دانلود |
