چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام افسر | اول |
| حسن سلیمانپور | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: Therapeutic Hypothermia, Traumatic Brain Injury, Targeted Temperature Management, Emergency Care |
| خلاصه مقاله | Background: Therapeutic hypothermia has demonstrated its capacity to protect neural functions in preliminary research on traumatic brain injuries (TBI), encompassing severe brain trauma, axonal damage, subdural hematoma (SDH), and subarachnoid hemorrhage (SAH). This effect is achieved through the reduction of metabolic requirements, inflammation, and excitotoxicity. Methods: This review article encompasses both clinical and preclinical research that explores the use of targeted temperature management in patients with TBI. An extensive search of the literature was performed using databases such as PubMed, Web of Science, and Scopus, covering publications up to December 2024. The search employed specific keywords associated with different types of TBI and hypothermia to locate relevant studies. The management of bibliographic records was facilitated through Endnote software. Two independent reviewers, who were blinded to each other's assessments, reviewed and evaluated the articles. Any differences in opinion were resolved through a consensus process. Information extracted from these studies included details such as the authors, year of publication, country where the study was conducted, the design of the study, interventions used, size of study samples, outcomes observed, and the conclusions drawn. Results: Therapeutic hypothermia's effectiveness in treating TBI shows variable clinical results. In cases of severe TBI, this approach may help control intracranial pressure and enhance recovery among younger patients with removed mass lesions; however, its efficacy diminishes with diffuse injuries. While axonal injury models demonstrate structural preservation, corroborative human data remains scarce. Studies in animals with subdural hematoma (SDH) point to potential reductions in edema and mortality, yet results from human trials are inconsistent. In subarachnoid hemorrhage (SAH), early-stage research suggests a decrease in oxidative stress and infarction, but the clinical impact on vasospasm and survival varies. Major challenges in this field include differences among patient populations, variations in treatment protocols, and potential systemic risks. Conclusion: Research indicates the necessity for uniform protocols, accurate patient selection based on precision, and the incorporation of comprehensive neuromonitoring techniques to enhance the effectiveness of therapeutic hypothermia in TBI. Healthcare providers should meticulously assess the potential risks and advantages, applying this treatment selectively within patient populations that are supported by empirical evidence. Cooperative initiatives are essential to bridge gaps between research and clinical practice, thereby improving the application of therapeutic hypothermia in TBI management strategies. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Therapeutic Hypothermia for Traumatic Brain Injuries.pdf | 1404/10/14 | 157976 | دانلود |
| Certificate.pdf | 1404/10/14 | 324995 | دانلود |
| Plan.pdf | 1404/10/14 | 3520263 | دانلود |
