چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامد ابراهیم زاده لیل آبادلو | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Gut Microbiota، Irritable Bowel Syndrome، Firmicutes |
| خلاصه مقاله | Introduction: The gut microbiota plays a key role in maintaining gastrointestinal health. Irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder, has multifactorial and largely unclear causes. This study aimed to compare the intestinal bacterial composition of healthy individuals with patients across different IBS subtypes. Material and Methods: Stool samples were collected from 38 healthy in individuals and 40 patients diagnosed with IBS. Total genomic DNA was extracted from each sample. Quantitative polymerase chain reaction (qPCR) ta rgeting the 16S rRNA gene was employed to quantify the relative abundance of Bacteroides and Firmicutes. Results: The relative abundance of Firmicutes was lowest in healthy individuals and highest in patients with IBS, particularly in those with the constipation-predominant subtype (IBS-C). In contrast, Bacteroides levels were highest in healthy individuals and lowest in IBS-C patients. While an increased Firmicutes-to-Bacteroides (F/B) ratio was observed across all IBS subgroups, this difference did not reach statistical significance. Conclusion: The observed changes in gut dysbiosis, particularly the imbalance between Firmicutes and Bacteroides, suggest a potential role in the pathophysiology of IBS. These changes may be a risk factor for the development of different subtypes of IBS. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate-1.pdf | 1404/10/14 | 132374 | دانلود |
| Gut Microbiota Alterations.jpg | 1404/10/14 | 612072 | دانلود |
