چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید کاظم میری نژاد | اول |
| محمد حسین صومی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: Rectal cancer; Tumor size; Prognosis; Overall survival; Disease-free survival |
| خلاصه مقاله | Introduction: Tumor extension assessed by T classification is a well-established prognostic factor in rectal cancer; however, the prognostic value of actual tumor size remains controversial. Maximum tumor diameter may better reflect tumor burden and biological aggressiveness, yet its role in predicting long-term survival has not been fully clarified. This study aimed to evaluate the impact of primary tumor size on overall survival (OS) in patients with rectal cancer undergoing curative surgery. Methods: A retrospective cohort study was performed on 182 consecutive patients with rectal cancer who underwent curative surgical resection. Tumor size was measured macroscopically using a hand ruler during pathological examination and analyzed as a categorical variable. Receiver-operating characteristic (ROC) curve analysis was applied to determine the optimal cutoff point for prognostic stratification based on sensitivity and specificity. Overall survival was evaluated using Kaplan–Meier survival curves, and differences between groups were assessed using the log-rank test, with statistical significance defined as P < 0.05. Results: The study population included 101 men (55.5%) and 81 women (44.5%), with a mean age of 57.8 ± 14 years. ROC analysis identified 5 cm as the optimal cutoff value for tumor size (AUC = 0.61). Patients were stratified into tumors ≤5 cm and >5 cm. During a median follow-up of 38 months, 90 patients (49.5%) died. One-, three-, and five-year OS rates were significantly higher in patients with tumors ≤5 cm compared with those with tumors >5 cm (92%, 65%, and 53% vs. 74%, 52%, and 40%, respectively; P = 0.02). Discussion: The findings demonstrate that primary tumor size is a significant prognostic factor for overall survival in rectal cancer. While T classification reflects depth of invasion, tumor diameter provides complementary prognostic information related to tumor burden, hypoxia, and the potential for nodal involvement and micrometastatic spread. These results are consistent with previous studies indicating that larger tumor size is associated with poorer outcomes in colorectal malignancies. Conclusion: Primary tumor size independently predicts overall survival in rectal cancer patients. Incorporating tumor size into routine prognostic assessment may enhance risk stratification and support more individualized postoperative management strategies. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate-RC tumor size.pdf | 1404/10/07 | 130060 | دانلود |
| ICGH2025.Impact of primary tumor size on survival.jpg | 1404/10/07 | 1842513 | دانلود |
