چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامد ابراهیم زاده لیل آبادلو | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Escherichia coli is a common intestinal bacterium, but certain pathotypes may contribute to inflammatory bowel disease (IBD). This study aimed to identify the pathotypes of E. coli isolated from Iranian patients with ulcerative colitis and explore their potential association with disease severity. Material and Methods: Stool samples were obtained from 38 Iranian patients with confirmed ulcerative colitis. Escherichia coli isolates were recovered and analyzed for different pathotypes using multiplex PCR with specific virulence gene markers. Clinical data, including disease severity, were collected to evaluate potential associations between E. coli pathotypes and disease outcome. Results: Among the Escherichia coli isolates, the most prevalent pathotypes were enterotoxigenic (ETEC) and diffusely adherent (DAEC), while other pathotypes were detected less frequently. ETEC was more commonly recovered from patients with moderate to severe disease, indicating a possible association with disease progression. Although no statistically significant correlation was observed between specific pathotypes and overall disease severity, the predominance of ETEC and DAEC highlights their potential involvement in the clinical course of ulcerative colitis. Conclusion: ETEC and DAEC are the dominant E. coli pathotypes in patients with ulcerative colitis and may contribute to disease severity. These findings highlight the potential role of specific E. coli pathotypes in the clinical course of the disease and support further research into targeted therapeutic strategies. |
| کلمات کلیدی | Escherichia coli، Pathotypes ، Ulcerative Colitis |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate-1.pdf | 1404/10/07 | 130678 | دانلود |
| Analysis of Escherichia coli Pathotypes in Stool Samples of Iranian Individuals with Ulcerative Colitis.jpg | 1404/10/14 | 618482 | دانلود |
