چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مریم عاشورپور |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 89396 |
| عنوان فارسی مقاله | نقشهای Sirtuin-1 در گلیوبلاستوما: از پیشرفت تومور تا درمان هدفمند |
| عنوان لاتین مقاله | Roles of Sirtuin-1 in Glioblastoma: From Tumor Progression to Targeted Therapy |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | چهاردهمین کنگره علوم اعصاب پایه و بالینی |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1404 |
| سال انتشار/ارائه میلادی | 2025 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1404/09/19 الی 1404/09/21 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://bcncongress.ir/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر قربانی حق جو | دوم |
| مریم عاشورپور | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Title: Roles of Sirtuin-1 in Glioblastoma: From Tumor Progression to Targeted Therapy Introduction: Glioblastoma (GBM) is the most prevalent and aggressive type of brain cancer in adults, presenting significant treatment problems due to its rapid proliferation, adverse prognosis, and treatment resistance. Existing treatments are still limited to surgery, chemotherapy, and radiotherapy. Evidence indicates that epigenetic mechanisms, including histone deacetylases (HDACs) and, in particular, sirtuins (SIRTs), are crucial in gliomagenesis. Among them, SIRT1, a member of the family, is a crucial regulator of genomic stability and apoptosis, serving as a dual effector in cancer cells. The goal of this review is to investigate the function of SIRT1 in GBM. Methods: From 2000 to 2025, we searched the keywords 'SIRT1' and 'glioblastoma' in a number of databases, including PubMed, Scopus, and Google Scholar. Results: Studies have shown that SIRT1 plays a key role in growth, cell survival, and apoptosis in GBM. Its activation or overexpression resulted in the downregulation of adhesion molecules VCAM-1 and ICAM-1, inhibition of monocyte adhesion, and regulation of tumor microenvironment signaling pathways. Small molecule activators of SIRT1, such as Comp 5, induced cell death through autophagy and mitophagy and inhibited cell proliferation. SRT2183, another activator, prompted cell cycle arrest, apoptosis, and growth suppression in glioma cells by increasing the pro-apoptotic protein Bim and decreasing Bcl-2 and Bcl-xL. The compound also induced autophagy and affected acetylation and phosphorylation of NF-κB and STAT3. Conclusion: Activation of SIRT1 using small molecule compounds such as Comp 5 and SRT2183 suppresses GBM cell growth, triggers apoptosis and autophagy/mitophagy, and regulates signaling pathways associated with the tumor microenvironment. These findings suggest that SIRT1 may serve as a potential therapeutic target in GBM, and its activation could facilitate the development of novel therapeutic strategies and improve treatment response in patients with GBM. |
| کلمات کلیدی | Keywords: Sirtuin-1, Glioblastoma, Therapeutics, Signaling pathways |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| PrintCerPDf2.aspx.pdf | 1404/10/03 | 727809 | دانلود |
| New Microsoft PowerPoint Presentation.pdf | 1404/10/03 | 249076 | دانلود |
