چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرانک علمی | اول |
| عفت علیزاده | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Mesenchymal stem cells (MSCs) exhibit exceptional properties such as multipotency, proliferation, and regenerative abilities. To ensure sufficient cell numbers for clinical applications, it is crucial to extend their passage in culture. However, prolonged culture leads to aging in MSCs, characterized by reduced proliferation, diminished stemness and differentiation capabilities, impaired homing abilities, and lower immunomodulatory functions. This aging process poses significant challenges for regenerative medicine and cell therapy. Herbal preconditioning has emerged as a promising strategy to address these issues, offering benefits like reducing chemotherapy side effects, enhancing MSC migration, protecting against oxidative stress, and improving therapeutic effectiveness. Researchers have explored herbal preconditioning as a viable method to delay or reverse MSC senescence during in vitro cultivation. This review focuses on the morphological, biological, and phenotypic changes in senescent MSCs, examining the mechanisms of MSC aging and presenting innovative strategies to rejuvenate these cells through herbal treatments. |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| h.pdf | 1404/09/11 | 452767 | دانلود |
| 2.pdf | 1404/09/11 | 1133698 | دانلود |
