چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| نرجس صدیقی | اول |
| مهدی طالبی | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Objective: Acute Myeloid Leukemia (AML) is a complex malignancy requiring advanced diagnostic tools. Exosomes carry non-coding RNAs (ncRNAs) like miRNAs, lncRNAs, and circRNAs, which regulate gene expression and tumor progression. Exosome-derived ncRNAs from AML patients are promising non-invasive biomarkers for diagnosis, disease stratification, and treatment monitoring. They offer potential for improving diagnostic accuracy, predicting therapy responses, and tracking minimal residual disease (MRD). This systematic review explores the role of exosome-derived ncRNAs in AML, focusing on their potential applications in improving diagnostic accuracy, predicting therapeutic responses, and monitoring minimal residual disease (MRD), thereby advancing personalized medicine in AML management. Materials and Methods: This systematic review examines the role of exosomes in leukemia, focusing on their ncRNA content in relation to potential diagnostic and prognostic biomarkers. A comprehensive search of PubMed, Scopus, Embase, and Web of Science was conducted, according to PRISMA guidelines with keywords such as AML, Acute Myeloid Leukemia, exosome, and tumor-derived exosome. All English original articles without time limitations were included in our studies. Results: Based on previous clinical studies, several non-coding RNAs derived from exosomes of AML patients, including miR-542, miR-216b, miR-10a-5p, miR-10b, miR-155-5p, miR-100-5p, miR-146b-5p, let-7a-5p, miR-92a, miR-125b, miR-26a-5p, miR-101-3p, miR-21, and SNHG1, were found to be overexpressed and higher in AML patients compared to healthy controls. In contrast, other non-coding RNAs, such as miR-146a, miR-34a, miR-192, miR-23b-5p, miR-339-3p, miR425-5p, miR-185-5p, miR-4433b-3p, miR-199a-5p, miR-451a, miR-151a-3p, LINC00265, LINC00467, and UCA1, were significantly lower in AML patients compared to healthy controls. These non-coding RNAs have been suggested to be useful as predictive and prognostic biomarkers in AML. Additionally, high expression of microRNA-532 has been associated with favorable overall survival in AML patients. Conclusion: Exosome-derived ncRNAs show promise as noninvasive biomarkers for AML diagnosis, prognosis, and therapy monitoring, advancing personalized medicine and improving clinical outcomes through targeted strategies. |
| کلمات کلیدی | Acute myeloid leukemia, ncRNA, Non coding RNA, exosome |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| AbstractBook.pdf | 1404/08/22 | 270238 | دانلود |
| New Microsoft Word Document.pdf | 1404/10/06 | 113339 | دانلود |
