چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| عفت علیزاده | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Non coding RNAs, Hepatocellular Carcinoma, Tumor suppressor miRNAs |
| خلاصه مقاله | Despite the considerable advancements in therapeutic strategies for hepatocellular carcinoma (HCC) in recent years, the prognosis for patients remains unfavorable. The possible reasons are late-stage diagnosis, ineffective chemotherapy, high rates of recurrence, and the absence of robust molecular targeting. Thus, a multitude of non-coding RNAs (ncRNAs) linked to HCC, where ncRNA expression levels may fluctuate throughout the progression of the disease, similar to other oncogenic molecules in cancer. The goal of this review is to examine and scrutinize targeting ncRNAs in order to enhance tumor suppressive miRNAs expression in HCC. Recent reports indicated that, targeting ncRNAs at various stages of the HCC could enhance the potential of treatment. A long non-coding RNA (lncRNA) and a circular RNA (circRNA) have been documented that could sequester tumor suppressor miR-138-5p. Hence, to retain the full capacity and function of miR-138-5p and other tumor suppressor miRNAs in HCC, targeting their inhibitor ncRNAs seems necessary. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Full EA-26 Aban.pdf | 1404/08/26 | 438658 | دانلود |
| EA certificate.pdf | 1404/08/20 | 722567 | دانلود |
