چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کمال کاظمی | اول |
| ناصر هاشمی گورادل | دوم |
| فاطمه بادی پا | سوم |
| معصومه امانی دولاما | چهارم |
| عفت علیزاده | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Colorectal cancer, Exosome, Non-coding RNAs, PD-1/PD-L1 signaling, Immune scape |
| خلاصه مقاله | Introduction: Still, colorectal cancer (CRC) is considered to be the leading cause of cancer-related mortality worldwide despite the many attempts that have been made to prevent its progression. The PD-1/PD-L1 signaling pathway plays a crucial role in local immunosuppression within the tumor microenvironment. PD-L1 is frequently found in human cancers and on activated T cells. When PD-L1 binds to its receptor, it inhibits anti-tumor immune responses by blocking the activation signals of T cells. Recent advances have highlighted the role of exosomes (small extracellular vesicles) as key mediators of intercellular communication, transferring various bioactive molecules, including proteins, metabolites, amino acids, and non-coding RNAs. Such exosomal non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a key role in CRC tumorigenesis and metastasis within the tumor microenvironment by regulating the PD-1/PD-L1 signaling pathway. Therefore, they can be used as potential novel cancer biomarkers and immunotherapeutic targets. This review article explores the association of exosomal microRNAs and the PD-1/PD-L1 signaling pathway in CRC. Methods: We conducted a comprehensive search in the PubMed and Google Scholar databases using keywords such as CRC, exosome, microRNA, PD-L1, and immunotherapy to identify original research articles that investigated the role of exosomal microRNAs in modulating the PD-1/PD-L1 pathway in CRC. Results: Exosomal miR-17-5p fromCRC stem cells inhibits SPOP, an E3 ubiquitin ligase, which leads to the stabilization of PD-L1 and a decrease in anti-tumor immune responses. This process promotes the proliferation of CRC cells and reduce the infiltration of CD8+ T-cells. Additionally, exosomal miR-372-5p from CRC cells diminish PTEN levels, which activates the PI3K/AKT/NF-κB signaling pathway, resulting in increased PD-L1 expression in macrophages and tumor cells. Exosomal circEIF3K derived from cancer-associated fibroblasts enhances the progression ofCRC through the miR-214/PD-L1 pathway. Exosomes derived from tumor cells containing lncRNA KCNQ1OT1 facilitate immune evasion in CRC by targeting the miR-30a-5p/USP22 pathway, which leads to the suppression of PD-L1 and dampens the response of CD8+ T-cells. Conclusion: Exosomal Non-coding RNAs play a pivotal role in modulating PD-L1 expression in CRC, enabling tumor immune evasion and progression. The findings of this work may help control and eradicate CRC by utilizing exosomal RNA content. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate.pdf | 1404/09/30 | 2665447 | دانلود |
| absrtact book.pdf | 1404/09/30 | 315115 | دانلود |
