چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کمال کاظمی | اول |
| رضا صلاحلو | دوم |
| ناصر هاشمی گورادل | سوم |
| بابک نگاهداری | چهارم |
| عفت علیزاده | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Colorectal cancer, CTL, Vaccine, TOMM34, Immunotherapy |
| خلاصه مقاله | Peptide vaccines consist of short sequences that mimic specific parts of tumor antigens, thereby enhancing the immune system's ability to destroy colorectal cancer cells (CRC). Translocase of Outer Mitochondrial Membrane 34(TOMM34), a mitochondrial transport protein, is found to be overexpressed in CRC and serves as a tumor-associated antigen. Our goal was to identify CTL epitopes in TOMM34 that are restricted by the HLA-B*0702 molecules to enhance the applicability of TOMM34-based immunotherapy. After retrieval of the amino acid sequence of the TOMM34, CTL epitopes were discovered using three advanced servers. Epitopes were screened based on their antigenic and immunogenic properties using VaxiJen v2.0 and IEDB Class I Immunogenicity tools, respectively. The KPLLRRASA epitope with ideal properties was selected. The complex docking was calculated with the lowest RMSD value of 0.361214 Å. These findings suggest that the identified HLA-B*0702 restricted epitope could be a candidate for immunotherapy in colorectal cancer. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate of biotech congress.JPG | 1404/08/17 | 155667 | دانلود |
| article.docx | 1404/08/17 | 1381707 | دانلود |
| poster.JPG | 1404/08/17 | 2017093 | دانلود |
