چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهه رحیم پور | دوم |
| ابوالقاسم جویبان | سوم |
| زهرا کریم زاده | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | The development of metal nanoparticle-based facile spectrophotometric assays for drugs is an emerging area of current scientific research. In this present investigation, Daclatasvir dihydrochloride (DAC) was used as one of the common oral therapies for the chronic hepatitis C virus for detecting therapeutic range. As recognizing the therapeutic range of drugs could offer a hopeful perspective, hence, the development of an eco-friendly, easy, fast sensitive, and selective approach has drawn massive attention for DAC detection in biological samples. In the present study, sucrose-capped gold nanoparticles (Suc-AuNPs) were synthesized and used as a nanoprobe for the DAC detection using its localized surface plasmon resonance (LSPR) property. The determination mechanism was experimentally shown using transmission electron microscope (TEM) measurements, dynamic light scattering and UV-Vis. The DAC detection is accompanied by the color change from pink to blue following a decrease in the LSPR band of Suc-Au NPs after adding various concentrations of DAC. Under the optimum condition, a good limit of detection with a linear concentration-response, high stability, simplicity, and repeatability were obtained which can be considered as a routine method in clinical laboratories. |
| کلمات کلیدی | Response Surface Method, Sucrose-Gold Nanparticle, Spectrophotometry, Daclatasvir |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 5. daclatasvir-certificate.pdf | 1404/08/15 | 440827 | دانلود |
| 5. daclatasvir-article.pdf | 1404/08/15 | 259005 | دانلود |
