چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم کوه سلطانی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Nanodiagnostics, Diagnostic Methods, Oral Cancer |
| خلاصه مقاله | Introduction: Nanodiagnostics are emerging detection systems that are superior to existing diagnostic agents. Nanoparticles are more biocompatible, able to target specific surface molecules, and are easier to synthesize. In imaging, nanoparticles provide higher image resolution and contrast. Therefore, nano-based techniques can help in the diagnosis and management of oral cancer at different stages. Methods: Online published articles between 2000 and 2025 were reviewed. Results: The range of applications of nano-based systems include: 1- MRI imaging: Nanocontrast agents in this technique have a longer half-life in blood circulation and have greater relaxivity. The limitation is the high cost. 2- Photoacoustic imaging: Nanosensors provide enhanced photoacoustic signals, especially in cases of micrometastases. The limitation is that it is difficult to obtain real time images. 3- Nano-based ultra-sensitive biomarker: This technique has greater sensitivity in detecting low concentrations of various biomarkers in tissue samples or body fluids of cancerous patients. 4- Quantum Dots (QDs) Imaging: Quantum dots exhibit high fluorescence intensity, good stability against color fading, and low nonspecific adhesion. However, the cytotoxicity and biodegradability of quantum dots in body need to be improved. 5- Diffuse reflection imaging: Gold nanorods have shown good results for screening oral malignancies and also for identifying residual disease during surgery. Conclusion: Nano-based diagnostic methods are convenient, cost-effective, and provide real-time imaging for oral cancer diagnosis. They enable targeted molecular imaging, detection of surgical margins during surgery, and serve as prognosticator. |
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