چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ناهیده قره آغاجی | اول |
| بهارک دیوبند | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Graphene oxide, Nanocomposite, Fluorescence imaging, Magnetic resonance imaging |
| خلاصه مقاله | Graphene oxide (GO) with porous structure has attracted a great attention owing to its large surface area, low toxicity, water solubility, and photothermal properties [1]. GO with a two-dimensional structure provides possibility of magnetic resonance imaging (MRI) contrast agents encapsulation. We investigated MRI contrast enhancement property of Gd3+/GO/alginate nanocomposite in our previous study [2]. The present study aimed to investigate the fluorescence imaging ability of the nanocomposite. We prepared Gd3+/GO/alginate nanocomposite using sonochemical-assisted freeze drying method. XRD, TEM, SEM, and MTT tests were performed to determine the structure, morphology, size, and cytotoxicity of the nanocomposite. Fluorescence spectrometry was carried out to analyze fluorescence property. TEM and SEM images showed that the sheet size of the nanocomposite and its average thickness were 100 and three nm, respectively. MTT results indicated cytocompatibility of the nanocomposite. Gd3+/GO/alginate showed a broad emission band appeared between 400-800 nm with excitation wavelength of 280-650 nm As conclusion, Gd3+/GO/alginate nanocomposite is a good potential candidate for fluorescence imaging. Since the nanocomposite has the ability to act as an MRI T1 contrast agent based on our previous study, it can be considered as a bimodal contrast agent for MRI/fluorescence imaging. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract Fluorescence Imaging.JPG | 1404/06/22 | 124856 | دانلود |
| Certificate Fluorescence Imaging.jpg | 1404/06/22 | 1071171 | دانلود |
