چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| نسترن جوان | اول |
| رضا قوطاسلو | دوم |
| حسین صمدی کفیل | سوم |
| محمد یوسف معمار | چهارم |
| جاوید صادقی | پنجم |
| حامد ابراهیم زاده لیل آبادلو | ششم |
| پردیس قوطاسلو | هفتم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | multi-drug resistant, Klebsiella pneumoniae, treat |
| خلاصه مقاله | New promising approaches to treat multidrug resistant klebsiella pneumoniae Introduction • Antimicrobial resistance (AMR) is one of the biggest challenges in microbiology and some solutions in bacteria to deal with antibiotics include innate or acquired mechanisms, reduce the drug penetration, alteration the drug targets, enzymatic inactivation of drugs, multidrug efflux pumps and biofilm formation. Multi drug resistant (MDR) is a term that the bacteria have resistance to three or more antimicrobial classes (1,2). K. pneumoniae (Kp) is Gram negative, commensal, ubiquitous, opportunistic, rod-shaped, non-motile that has a polysaccharide capsule (3) with a wide range of community-acquired and nosocomial infections (4).The aim of this study was search the possible treatments against MDRKp.• Materials & Methods • In order to answer this topic, our search was performed in google scholar and PubMed from September 23, 2023 to September 29, 2023 and first of all to get the best and comprehensive results, keywords of multi-drug resistant, Klebsiella pneumoniae and treat were selected.• Results • We have found many bacteriophages specially their cocktails are tools that the absence any immunity response against them in our body is the most reason also nanoparticles and Nano-antibiotic by use of nanotechnology are well developed that can be useful. CRISPR-Cas system, Antimicrobial peptides, odilorhabdins, Drug delivery systems (DDSs), Fecal transplant therapy(FTT) and double-carbapenem therapy (DCT) are new tools so require more research. Due to the extracellular nature of Klebsiella pneumoniae, antibody drug conjugation and some of the engineering are done on its structure are useful. Nontoxic Bacteriocins are peptides that thorough translocation pathways infiltrate to target bacteria which produce by lactic acid bacteria (LABs) and probiotics, prebiotics and their supernatant specially from LABs have shown the brilliant results. Predatory bacteria (living antibiotics) due to their morphology are used to treat infections by Gram negative bacteria also antibacterial oligonucleotides by their adjuvant role in combination with antibiotics are effective.• Conclusion • In the current study, to treat MDR Klebsiella pneumoniae, we found different valuable approaches like Phage therapy, Antimicrobial peptides, Nanotechnology, Antibody drug conjugation, Antimicrobial oligonucleotides, Nano antibiotic, Crispr-Cas System, Bacteriocins, Probiotics, some techniques like FTT and DCT and DDS, Predatory bacteria, Antibacterial oligonucleotides, Combined antibiotics and finally synthetic lipopeptide but nowadays, considering the importance of multi drug resistant in Klebsiella pneumoniae and its easy and quick distribution among the people, especially the hospitalized patients, more studies are needed in this field to find the best approaches with the least complications. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| new.pdf | 1404/04/23 | 224049 | دانلود |
| new.jpg | 1404/04/23 | 353891 | دانلود |
| participate.jpg | 1404/04/23 | 323743 | دانلود |
