| خلاصه مقاله | Introduction:
Infertility is a condition characterized by the inability to conceive after 12 months or more of regular unprotected sex. It is considered acomplex disorder with wide-ranging biological, psychological, social, and economic consequences and is a significant health issue globally. A successfulpregnancy occurs due to the coordinated interaction between a man's and a woman's physiological events. Although traditional treatments such as ovulationinduction drugs, surgical interventions, and assisted reproductive technologies (ART) such as in vitro fertilization (IVF) and intrauterine insemination (IUI) areeffective, they often involve high costs, emotional stress, and low success rates. Tissue engineering has emerged as a powerful tool to treat infertility andimprove health with the help of advanced medical science technologies.
Methods:
tissue-engineered Scaffold systems containing cells are essential for regenerating reproductive organs. Using scaffolds in the treatment of thesediseases offers a promising approach for young infertile couples. Scaffolds should be biodegradable, biocompatible, porous, and suitable mechanicalproperties to mimic natural extracellular matrix (ECM).
Results:
Among tissue engineering technologies, 3D printing has attracted increasing attention in the last decade. It is widely used to create complexscaffolds with suitable materials for various applications. 3D printing has advanced with the development of cell sources and biomaterials, offeringalternatives that overcome the disadvantages of traditional infertility treatment techniques and provide scaffolds to create functional tissues to replacedamaged human tissues. 3D microprinted scaffolds create an excellent ECM-like environment for cell growth and target tissue repair. Also, 3D printing hasshown a high potential in reconstructing damaged reproductive tissues and treating infertility. The accuracy of 3D printing allows the creation of complexforms by adding layer upon layer of different materials, which is a valuable tool for creating biomimetic scaffolds with controlled properties, with the ability tocreate customized structures and patient-specific scaffolds. These three-dimensional structures with microporous features can be produced through acomputer-controlled layer-by-layer process.
Conclusion:
In recent years, significant progress has been made in the field of reproductive organ tissue reconstruction and infertility treatment with thehelp of 3D printing. For example, 3D-printed biosynthetic ovaries using microporous scaffolds are highly precise and offer customization previouslyunattainable in infertility treatment. The main advantage of 3D printing is its ability to produce patient- and tissue-specific scaffolds, which makes it unique.Moreover, this research aims to investigate the potential of 3D printing scaffolds in treating infertility and create new opportunities in this field. |