چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | امین عباسی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده تغذیه |
| کد مقاله | 87830 |
| عنوان فارسی مقاله | THE EFFECT OF SAFFRON EXTRACT ON OXIDATIVE STRESS MARKERS IN PATIENTS WITH FATTY LIVER DISEASE : A SYSTEMATIC REVIEW |
| عنوان لاتین مقاله | THE EFFECT OF SAFFRON EXTRACT ON OXIDATIVE STRESS MARKERS IN PATIENTS WITH FATTY LIVER DISEASE : A SYSTEMATIC REVIEW |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 8th Internationl Food, Agriculture, and Veterinary Sciences Congrees |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Turkey |
| شهر محل برگزاری کنگره/ همایش | Konya |
| سال انتشار/ ارائه شمسی | 1404 |
| سال انتشار/ارائه میلادی | 2025 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1404/03/08 الی 1404/03/10 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.gthk.org/english |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Food Science and Technology Faculty of Nutrition and Food Sciences Tabriz University of Medical Sciences Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| امین عباسی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Fatty liver disease (FLD) is characterized by the accumulation of fat in the liver, often leading to inflammation and oxidative stress, which contributes to disease progression. Saffron extract, derived from Crocus sativus, is known for its potent antioxidant properties. This systematic review aims to evaluate the effect of saffron extract on oxidative stress markers in patients with fatty liver disease. Methods: A comprehensive search was conducted across PubMed, Scopus, and Web of Science for studies published between 2000 and 2024. Studies included were randomized controlled trials, clinical trials, and cohort studies that assessed the impact of saffron extract on oxidative stress markers (e.g., malondialdehyde, glutathione, superoxide dismutase) in patients with fatty liver disease. Inclusion criteria were studies with appropriate control groups and baseline measures of oxidative stress. Results: A total of 12 studies met the inclusion criteria. Analysis of pooled data demonstrated that saffron extract supplementation significantly reduced oxidative stress markers in patients with fatty liver disease. Specifically, saffron extract led to a significant reduction in malondialdehyde (MDA), a marker of lipid peroxidation, and an increase in antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). These changes were associated with improvements in liver function indicators, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting a potential protective effect against liver damage. The doses of saffron extract used in the studies ranged from 20 mg to 200 mg per day, with the most significant effects observed at higher doses and longer intervention periods (≥8 weeks). Conclusion: Saffron extract appears to have a beneficial effect on reducing oxidative stress markers in patients with fatty liver disease, potentially offering a therapeutic option for mitigating liver damage associated with this condition. Further large-scale, long-term studies are needed to confirm these findings and determine the optimal dosage and duration of saffron extract supplementation for managing oxidative stress in fatty liver disease. |
| کلمات کلیدی | Keywords: Saffron extract, oxidative stress, fatty liver disease, antioxidant, malondialdehyde, superoxide dismutase, liver function, systematic review |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 87830.pdf | 1404/06/04 | 108132 | دانلود |
| Amin Abbasi-3.pdf | 1404/03/21 | 1351893 | دانلود |
