چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| داود خضرلو | اول |
| زهرا ولی بیگلو | دوم |
| سودا بهنام | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: Relapsing-Remitting Multiple Sclerosis(RRMS), brain Atrophy, corpus callosum |
| خلاصه مقاله | Introduction: Multiple sclerosis (MS) is an immune-mediated inflammatory and neurodegenerative disease causing cognitive and physical disability, resulting in high societal costs. In the pursuit of understanding the intricate mechanisms of MS, the study of brain atrophy—particularly the atrophy of the corpus callosum—stands as a pivotal area of research [1, 2]. In MS patients, inflammation and destruction of myelin around the Corpus Callosum may lead to atrophy of this structure. Corpus Callosum plays an important role in the transmission of information between the two hemispheres of the brain, and its destruction can lead to disorders in the communication between neurons and brain function. [1-3]. In this study atrophy in corpus callosum sub-regions was analyzed in relapsing-remitting multiple sclerosis(RRMS) patients. Methods and Materials: In this study, MRI images of 37 Relapsing-remitting Multiple Sclerosis (RRMS) patients with an average age of 42 [30-50]; and 12 healthy control (HC) participants were selected from Imam Reza hospital. Corpus callosum (CC) sub-regions were extracted using the Freesurfer V7.1 volumetric toolkit. Finally, the normalized CC volumes were compared between RRMS and HC groups. Statistical analysis was conducted using SPSS v27, utilizing a T-test with a significance level set at P<0.05. Results: Five corpus callosum sub-regions, and a total corpus callosum were extracted by Freesurfer. All CC regions in MS group are larger than HC group. Among these sub-regions posterior-CC, Anterior CC and total CC were significant between RRMS and HC groups by statistical P- value level as 0.008, <0.001 and 0.014 respectively. However, there was no statistical significance in Mild-posterior CC, Central CC, Mild-anterior CC sub-regions between two groups. Discussion: Multiple sclerosis has been considered a white matter disease, however, it seems only the corpus callosum (CC) appeared to be the brain structure with the highest rate of atrophy throughout the disease. In accordance with previous studies, in this study, Corpus callosal atrophy was not observed uniformly across the entirety of the CC. In this study, a highly significant difference (P<0.008) was found in the posterior CC and anterior CC subregions between the HC and RRMS groups, leading to significant total corpus callosum atrophy. Corpus callosal atrophy can be a potent biomarker for monitoring MS. |
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