چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| اسرا سادات طالبی زنوزی | اول |
| رقیه بداقی حسین ابادی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Targeted alpha particle therapy. Dosimetry. Cherenkov Luminescence Imaging |
| خلاصه مقاله | Background: Osteosarcoma is a type of aggressive bone cancer known for its formation of osteoid tissue and widespread presence of IGF1R, with some cases also showing expression of HER-2. These features create potential for utilizing alpha particle-emitting isotopes for targeted radiation therapy, specifically targeting bone-forming tumors and metastases expressing IGF1R or HER-2. Ac-22 is one of the alpha-emitting radionuclides commonly used in the treatment of osteosarcoma. Because alpha particles have short-range and high-energy deposition characteristics, it's crucial to gather precise data on dose distribution to optimize the effectiveness of this therapeutic method. Objective: Utilizing current individual dosimetry techniques, such as SPECT (Single-Photon Emission Computerized Tomography) and PET (Positron Emission Tomography) image-based dosimetry, in Targeted Alpha Therapy (TAT) encounters significant challenges and, at times, proves impractical. Hence, there is a pressing need to investigate alternative dosimetry approaches, such as Cherenkov luminescence image-based dosimetry. Methods: The Monte Carlo codes GATE (version 9.2) were utilized to simulate post-TAT Cherenkov Luminescence Imaging (CLI) in the MOBY mouse phantom. A tumor, with a diameter of 5 mm, was modeled within the femur, with Ac-225 uniformly distributed within the tumor. Personalized dosimetry accuracy was assessed by estimating the Root Mean Square Errors (RMSEs) between the acquired image-based Dose Volume Histograms (DVHs) and the reference DVHs. Results: The in-silico results demonstrated that the RMSE value is less than 1, indicating high accuracy. Additionally, our analysis revealed that the distribution of Cherenkov radiation closely aligns with the absorbed dose distribution within the tumor. Conclusion: Our findings suggest that Cherenkov emission holds promise for individual dosimetry in TAT. Cherenkov luminescence image-based dosimetry proves to be easily applicable in preclinical investigations, distinguished by its simplicity and effectiveness. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate Poster_2.pdf | 1404/02/16 | 171218 | دانلود |
| Untitled2.pdf | 1404/02/16 | 208674 | دانلود |
