چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سعید چارسوئی | اول |
| عنوان | متن |
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| خلاصه مقاله | Management of seizure related to Autoimmune encephalitis Saeid Charsouei,MD,Associate Professor of Neurology,Epilepsy Fellowship Neurology Department, Razi Hospital, Tabriz University of Medical Sciences Seizures are a very common manifestation of autoimmune encephalitis (AE), ranging from 33% to 100% depending on the antigen. In encephalitis with antibodies to neuronal extracellular antigens, autoantibodies play a direct role in disease pathogenesis. They have access to target antigens and can potentially alter the structure and function of antigens but induce relatively little neuronal death.Prompt immunotherapy is usually very effective, and long-term antiepileptic treatment may not be needed. In contrast, in encephalitis with antibodies against intracellular antigens , autoantibodies may not be directly pathogenic but serve as tumor markers. These autoantibodies cannot reach intracellular target antigens and are considered to result from a T-cell-mediated immune response against antigens released by apoptotic tumor cells, which contain nerve tissue or express neuronal proteins. Neuronal loss is frequently described and predominantly induced through cytotoxic T-cell mechanisms. They often exhibit an inadequate response to immunotherapy and require early tumor treatment. Long-term antiepileptic treatment is usually needed. Treatment for suspected autoimmune encephalitis is often given empirically prior to specific antibody test results. This may include steroids and/or IVIG. If a cell-surface/synaptic antibody disorder is diagnosed, initial treatments may include IVIG, plasmapheresis, and/or steroids. |
| کلمات کلیدی | seizure,encephalitis,Autoimmune |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Govahi.pdf | 1404/02/15 | 124629 | دانلود |
| Management of seizure related to Autoimmune encephalitis.docx | 1404/02/15 | 13105 | دانلود |
| Management of Seizure related to Autoimmune Encephalitis FINAL (1).pdf | 1404/02/15 | 2175181 | دانلود |
