| خلاصه مقاله | Introduction
The present systematic review aimed to investigate more upto-date and detailed effects of prebiotic dietary fibers,
probiotics, and synbiotics as a proposed strategy for intestinal
permeability and immunity.
Methodology
A systematic literature search of the Embase, PubMed, Web of
Science, and Scopus electronic databases and a hand-searched
reference list was conducted from the inception of databases
up to May 2024. About 36 studies were included for review
Results
According to the evidence presented in this study, prebiotic
whole foods or food enriched with prebiotics, probiotics, and
synbiotics may have favorable effects on serum levels of zonulin
as a measure of intestinal permeability. The effects on
glucagon-like peptide-2gut microbiota and their metabolites
such as long and short-chain fatty acids (LCFA/SCFA) and bile
acids were contradictory and inconclusive. The increases in the
levels of Bifidobacterium and increases in the levels of SCFA
with an intake of prebiotic supplements or food products
enriched with prebiotics have been indicated in some studies.
Fecal calprotectin as an important marker of local gut
inflammation, tumor necrosis factor-α, and high-sensitivity Creactive protein were not affected in most studies.
Conclusion
The non-replication of the results of the studies makes it
difficult to conclude the effects of prebiotics, probiotics, and
synbiotics on gut-related health and immunity. So, further
evidence is required before definitive recommendations can be
made. |