چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا محمودپور | اول |
| الهام احمدیان | سوم |
| محمد رضا اردلان | چهارم |
| سپیده زنونی واحد | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | kidney protective effects of hydroalcoholic extract of capparis spinosa seeds against cisplatin nehrotoxicity: invivo study Background and Aim: Capparis spinosa have high amounts of bioactive antioxidant components and is an important therapeutic plant in Persian medicine. Therefore the current study aimed to evaluate nephroprotective effects of Capparis spinose seeds hydroalcoholic extract against cisplatin(anticancer drug) induced nephrotoxicity in vivo Methods: Capparis spinosas whole ripe fruits from the Moghan province of Iran were collected. Herbarium confirmation of the plant species was obtained from Shahid Beheshti pharmacology faculty lab. Seeds of fruit were extracted. Powder prepared from seeds by grinder and dissolved in ethanol and water with a 70/30 concentration ratio, preserved at room temperature. 20 male Sprague Dawley rats with weights 220±20 gr in 4 groupswere assessed: Control group, cisplatin single dose 7 mg/kg intraperitoneally injected group, and 2 treatment groups with cisplatin 7 mg/kg IP single dose and different doses and of treatment by extract (50 and 100 mg/kg of extract for 1 day post-treatment group). Results were analyzed by ANOVA statistical method. Results: Serum creatinine mean level from 0.33 mg/dl in the control group increased to 1.84 mg/dl in the cisplatin group. But, the result was not significant (p<0.06). The mean serum creatinine level in groups treated with cisplatin in addition, 50 and 100 mg/kg CSE for one day was 1.43 mg/dl and 1.59 mg/dl respectively p<0.6 and p<0.7. SOD levels in the sham group were 1.65 IU/mg while cisplatin decreased its amount to 1.23 IU/mg treatment could increase SOD levels, although non-significantly. Kidney tissue GPX and TAC levels in the cisplatin group decreased compared to sham, whereas treatment with CSE could reverse these effects non-significantly. Kidney tissue IL-6 level as an essential inflammatory index evaluated in study groups. A significant increase was observed in cisplatin group 1344.88 pg/mL compared to sham 1176.52 pg/mL CSE treating in groups which received cisplatin then treated with 100 mg/kg of extract BID for 1 day lowered IL-6 level as 1023.01±380.84 significantly. P<0.01 The mean level of kidney tissue IL-?1 mean levels were increased from 234.76 pg/mL in the control group to 298.76 pg/mL in the cisplatin group. Also, IL-?1 mean level was 256.46 pg/mL in the group that received CSE. 100 mg/kg for one day. P<0.13 TNF-? means level in the sham group was 49.38 pg/mL and increased to 84.80 pg/ mL in the cisplatin group. The mean of TNF-? in the group treated with cisplatin and CSE 100 mg/kg for one day decreased to 64.36 pg/Ml. P<0.13 Conclusion: protective effects of the extract lowering serum creatinine , anti-oxidative and anti-inflammatory 492 1 st National Congress of PERSIAN MEDICINEeffects of CSE were seen in the kidney tissue. In this research study, Good nephroprotective effects were seen in post-treatment groups by CSE esspesialy with 100 mg/ kg doses.Capparis spinosa is an ancient therapeutic plant which could be used for kidney protection in patients with AKI. However clinical studies are needed to detect the proper doses of therapeutic and for commercial products preparations. Keywords: Capparis spinosa seeds; kidney; cisplatin; Persian Medicine |
| کلمات کلیدی | Keywords: Capparis spinosa seeds; kidney; cisplatin; Persian Medicine |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Doc1.docx | 1404/02/08 | 236181 | دانلود |
| Fariba Mahmoodpoor. 36.pptx | 1404/02/08 | 526651 | دانلود |
| gavahi.pdf | 1404/02/08 | 852575 | دانلود |
