چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| نرجس صدیقی | اول |
| مهدی طالبی | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and aim: Hematologic malignancies are a very diverse group of disorders related to the blood and bone marrow. The pathophysiology of hematologic malignancies has been linked to the aberrant expression of several non-coding RNAs (ncRNAs). Meanwhile, it has been found that some ncRNAs can encode small peptides or micropeptides due to the development of proteomics and translation technology. They are involved in several aspects of cancer. The aim of this study was to review the all ncRNA-encoded peptide in hematological malignancies and their potential roles in progression and protection. Methods: At the present review, articles in PubMed, Scopus and web of science were searched with the following terms: leukemia, hematological malignancy, noncoding RNA, encode, peptide either alone or in a combination form. The search was without time limitation and all English articles which was relevant to our aims, were selected. Results: After reviewing the published articles in the mentioned databases, we found 4 ncRNA with peptide secretion potential. APPLE is a kind of lncRNA transcript in acute myeloid leukemia (AML); this peptide can regulate the initiation step of translation by promoting PABPC1-eIF4G interaction, mRNA circularization, and eIF4F initiation complex. In addition, circHNRNPU_603aa and circCHEK1_246aa are peptides which secrete from circRNA involved in Multiple Myeloma; circHNRNPU_603aa encoded by circHNRNPU could significantly increase the growth rate of tumor cells. circHNRNPU-603aa mediates SKP2 selective splicing and competitively inhibits c-Myc ubiquitination, thereby up-regulating the splicing isomers of circHNRNPU603aa and SKP2-NM_001243120. CircCHEK1_246aa interacts with CEP170, and by upregulate NFATc1 expression, leading to MM cell proliferation, drug resistance, and bone disease formation. Recent research has found that CLLU1, a lncRNA, can encode a short peptide similar to interleukin-4. Its abnormally elevated expression is only found in chronic lymphoid leukemia, indicating malignant pathological features and poor prognosis. Conclusion: In conclusion, the present understanding of proteins encoded by circRNAs and lncRNAs in hematologic malignancies is comprehensively summarized in this review. In addition to discussing their diverse functions in controlling RNA and protein metabolism, this review emphasizes their potential for targeted therapy, disease prediction, and cancer diagnostics. In order to further study in this area, this review attempts to provide new insights and perspectives. |
| کلمات کلیدی | keywords: leukemia; hematological malignancy; noncoding RNA; encode; peptide. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 25_870_41cb6d3134f4b0a77670bcbfac1cb3ee (1).jpg | 1403/12/29 | 320170 | دانلود |
| abstract.pdf | 1403/12/29 | 156496 | دانلود |
