چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| طهورا فایقی ارجمند | اول |
| مریم قاسمی | دوم |
| احمد شجاعی | سوم |
| عفت علیزاده | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Mitochondrial DNA, Retinoblastoma, Applications, Mutations |
| خلاصه مقاله | Background: Retinoblastoma, as a rare childhood ophthalmic cancer, is challenging in early diagnosis and hard to treat. Mitochondrial DNA (mtDNA) is widely used in molecular biology research to recognize genetic alterations contributing to cancer development, progression, and treatment resistance. The tiny size, easy isolation, less genetic rearrangements, and high copy number for example up to 1000 copies make mtDNA a good candidate for study in the genetics of different diseases. In this regard, recent advances in mtDNA function have improved our knowledge of mitochondria DNA content in ocular cancer, and retinoblastoma. This review dissected recent discoveries of mtDNA content changes in retinoblastoma as a potential candidate for premature diagnosis and the development of innovative future therapeutics .Methods: Using the keywords “Retinoblastoma”, “Mitochondrial DNA”, “diagnosis”, and “treatment”, all articles were retrieved from Google Scholar, PubMed, and Scopus since 2010. Results: Some investigations in recent malignancies disclosed that small changes in the mtDNA can strongly affect nuclear DNA and subsequently affect tumorigenesis. In this way, several studies focusing on Retinoblastoma patients showed that mtDNA displacement (D)-loop mutations may take a part in retinoblastoma tumor establishment and progression . For instance, mt D-loop variations especially A73G was the most common mutation as well as the loss of mitochondrial complex I, were reported which also resulted in morphological changes of the mitochondria. Conclusion: In conclusion, mtDNA D-loop mutations probably direct the progression of tumors in Retinoblastoma and by identifying them novel biomarkers for early diagnosis and treatment of Retinoblastoma will be available. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| New Microsoft Word Document (1).pdf | 1404/01/30 | 537406 | دانلود |
| gc -01.jpg | 1404/01/17 | 3053900 | دانلود |
