چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مریم عاشورپور |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 86971 |
| عنوان فارسی مقاله | Sirtuin-1 در بیماری بهجت: مکانیسم ها، کارایی و چالش ها |
| عنوان لاتین مقاله | Sirtuin-1 in Behçet's Disease: Mechanisms, Efficacy, and Challenges |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | شانزدهمین کنگره بین المللی آزمایشگاه و بالین |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/10/01 الی 1403/10/03 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | /https://isacl.congressapp.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | Maryam Ashourpour Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم عاشورپور | اول |
| معصومه علی نژاد | دوم |
| امیر قربانی حق جو | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Sirtuin-1; Behçet’s Disease; Inflammation; Oxidative Stress; Therapeutics |
| خلاصه مقاله | Background and Aim: Behçet's disease (BD) is a chronic, relapsing, autoinflammatory disorder that impacts blood vessels of all types and sizes in various tissues and organ systems and is characterized by arthritis, intraocular inflammation, skin lesions, genital ulcers, and mouth ulcers. Sirtuin 1 (SIRT1) is the most studied member of the Sirtuin family and a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase that is involved in diverse physiological processes such as glucose metabolism, oxidative stress, inflammation, tumorigenesis, DNA stability, and aging. Studies suggest that SIRT1 may affect various critical pathways in BD. This review aims to evaluate the potential role of SIRT1 in Behçet's disease. Methods: From 2000 to 2024, we searched the keywords SIRT1 and Behçet's disease in several databases, including PubMed, Google Scholar and Scopus. Results: SIRT1 inhibits NF-κB signaling, diminishing pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, which are increased in BD.Additionally, SIRT1 decreases oxidative stress by upregulating antioxidant enzymes like superoxide dismutase (SOD) and catalase while promoting mitochondrial biogenesis. Initial research indicates that SIRT1 activators, such as resveratrol, may reduce inflammation and oxidative stress in BD. Conclusion: SIRT1 has antioxidant and anti-inflammatory functions in Behçet's disease, so increasing SIRT1 activity may be a promising strategy for treating BD, although further research is needed to confirm these benefits in clinical practice. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 25_652_1730516ae87eb1705d10529efb5edf5e.jpg | 1403/12/07 | 334222 | دانلود |
| article.docx | 1403/12/08 | 216105 | دانلود |
