چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | رویا صالحی قره ورن |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 86966 |
| عنوان فارسی مقاله | مقایسه جامع عملکرد هموستاتیک نانورس های طبیعی و مصنوعی تعبیه شده در اسفنج اصلاح شده مبتنی بر سلولز برای خونریزی های شدید |
| عنوان لاتین مقاله | A comprehensive comparison on hemostatic performance of natural and synthetic nanoclays embedded in modified cellulose-based sponge for non-compressible massive bleedings |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | یازدهمین کنگره بین المللی زخم و ترمیم بافت یارا |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tehran |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/08/30 الی 1403/09/02 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.wtrc.ir/fa/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمیه علی محمدی | سوم |
| رویا صالحی قره ورن | اول |
| شبنم صادقی | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | The importance of managing severe bleeding is crucial for patient rescue in both clinical and unexpected emergency situations. In this context, achieving rapid hemostasis with no stimulation of immune responses is essential. Although natural clays demonstrate high performance in controlling severe hemorrhage and have a low stimulatory impact, their large particle size and potential risk of thrombosis are considered significant drawbacks when compared to synthetic nanoclays. Conversely, the complex and costly synthesis process of synthetic nanoclays limits their scalability for commercial applications. To address these limitations, a novel approach using glow discharge plasma irradiation was applied to convert natural kaolin, sourced from the Marand mine in East Azerbaijan, into pseudohexagonal-shaped kaolin nanoparticles (30 to 150 nm) following planetary ball milling. This study represents a comprehensive comparison between hemostatic performance of natural and synthetic nanoclays embedded in modified cellulose-based sponge for non-compressible massive bleedings. Additionally, plasma irradiation may directly enhance the specific surface area and pore volume of nano kaolin, thereby improving the hemostatic performance of the nanocomposite aerogels. The triple-network carboxymethyl cellulose aerogels, crosslinked with Ca²⁺ , citric acid, and nano kaolin, exhibited a highly porous structure (~80%) and remarkable absorption of phosphate-buffered saline (PBS) (~3250%), which is effective in concentrating hemostasis-inducing proteins. Furthermore, these aerogels demonstrated high adhesion ability to wet tissue surfaces. The aerogels showed excellent performance in forming stable clots (BCI < 14%), with approximately 91% red blood cell attachment and 95% platelet aggregation. The in vivo host response, assessed through hematological, pathological, and biochemical parameter tests, revealed no systemic or significant local inflammatory response. The nanocomposite aerogels demonstrated superior performance, achieving a 2.5-fold and 2-fold reduction in hemostasis time and blood loss, respectively, in a rat femoral artery bleeding model compared to commercial hemostatic sponges (P-values < 0.01), respectively. Consequently, this innovative treatment of natural clays offers a viable solution by producing low-risk materials with reduced synthesis costs compared to synthetic nanoclays. The engineered nanocomposite aerogels, through the combination of optimized chemical properties and physical design, exhibited a synergistic effect by simultaneously activating the coagulation cascade and forming a physical barrier at the bleeding site, thereby minimizing side effects and mitigating the risk of thrombosis. |
| کلمات کلیدی | nano-kaolin, plasma glow discharge, superabsorbent, aerogels, hemostasis |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| A comprehensive certificate.pdf | 1403/12/06 | 759188 | دانلود |
| abstract 3.pdf | 1403/12/06 | 195313 | دانلود |
