چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | لیلا حسینی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | روانپزشکی و علوم رفتاری |
| کد مقاله | 86866 |
| عنوان فارسی مقاله | Protective Effects of Coenzyme Q10 against Aging‐induced Cognitive Impairments through Regulating Mitophagy |
| عنوان لاتین مقاله | Protective Effects of Coenzyme Q10 against Aging‐induced Cognitive Impairments through Regulating Mitophagy |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 13th Basic and Clinical Neuroscience Congress |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/09/21 الی 1403/09/23 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://bcncongress.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | Research Center of Psychiatry and Behavioral Sciences, Tabriz university of Medical sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| لیلا حسینی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | The behavioral effects and molecular signaling mechanisms of Coenzyme Q10 (Q10) in age-related memory impairment are poorly understood. This study aimed to investigate the effects of Q10 on memory impairment, oxidative stress, apoptosis, and mitophagy in aged rats. 40 aged (24 months old) and 10 young (3 months old) male Wistar rats were randomly divided into the following groups (n =10/group): young +vehicle, aged +vehicle, and aged +Q10 (at 100, 200, 300 mg/kg/day doses). Treatments were administrated orally by gavage for 2 weeks. The novel object recognition test was used to assess episodic memory. Oxidative stress, apoptosis, and mitophagy-related protein expressions were measured in the hippocampus. We found that Q10 reversed aging-induced memory impairment at the dose of 300 mg/kg. Moreover, aging was associated with a reduction in ATP production, a decrease in mitophagy-related proteins (PINK, Parkin, and P62 levels and LC3II/I ratio), excessive generation of reactive oxygen species and lipid peroxidation, and apoptosis in the hippocampus, which was partially reversed following oral administration of Q10. These findings indicate the therapeutic potential of Q10 in aging-induced memory decline. |
| کلمات کلیدی | Aging. Memory. Oxidative stress. Apoptosis.Mitophagy. Coenzyme Q10 |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract Aging.pdf | 1403/11/22 | 57262 | دانلود |
| Dr. Leila Hosseini (3).pdf | 1403/11/22 | 386444 | دانلود |
| Aging and Cognitive Function from Molecular Mechanisms to Interventions and Treatments (1).pdf | 1403/11/22 | 286724 | دانلود |
| BCNC2024-Abstract Book.pdf | 1403/11/22 | 2835430 | دانلود |
