چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مصطفی اکبرزاده خیاوی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های گوارش و کبد |
| کد مقاله | 86801 |
| عنوان فارسی مقاله | تاثیر نانوساختارهای هدفمند بر مسیر سیگنالینگ Nrf2/Kaep1 در سرطان کولورکتال |
| عنوان لاتین مقاله | Impacts of targeted nanostructures on Nrf2/Kaep1 signaling pathway in colorectal cancer |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | بیست و چهارمین کنگره بیماری های گوارش و کبد ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/09/13 الی 1403/09/16 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.iaghcongress.org/fa/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| اعظم صفری | اول |
| مصطفی اکبرزاده خیاوی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | nanostructures ، Nrf2، Kaep1 |
| خلاصه مقاله | The nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-related protein 1 (KEAP1) signaling pathway is widely recognized for its pivotal role in cellular defense mechanisms, particularly in protecting cells from oxidative stress and inflammation. This pathway modulates the expression of various antioxidant enzymes and detoxification proteins, thereby maintaining cellular homeostasis and reducing damage caused by reactive oxygen species (ROS) and other harmful agents. Dysregulation of the Nrf2/KEAP1 axis has been implicated in the progression of several diseases, including cancer. The nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-related protein 1 (KEAP1) pathway is well known to protect cells from oxidative stress and inflammation. The current study introduced an effective nanomedicine composed of PEGylated gold nanoparticles (GNP -PEG) conjugated with cetuximab (Cet) that can induce ROSs mediating apoptosis pathways for CRC treatment. The GNPs are synthesized, stabilized by polyethylene glycol (PEG), functionalized, and covalently conjugated with Cet. The physicochemical properties of engineered nanomedicine (GNP-PEG-Cet) were characterized by UV-vis spectrum. Then, the impact of GNP-PEG-Cet on cell viability, ROS production, and oxidative stress gene expression (Kaep1- Nerf2) were evaluated in the CRC cell line. The engineered nanomedicine effectively induced apoptosis in SW-480 cells and significantly reduced cancer cell viability. In addition, the maximum production of ROS was obtained after the treatment of cells with an IC50 dose of GNP-PEG-Cet. Based on real-time PCR data, in the treated SW-480 cells with the GNP-PEG-Cet, the expression level of Keap1 was significantly increased, while the expression of Nerf 2, were found to be significantly decreased as compared to the untreated control cells. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate.pdf | 1403/11/14 | 131348 | دانلود |
| Dr.Safari.pdf | 1403/11/14 | 532515 | دانلود |
