| خلاصه مقاله | Background:
Esophageal cancer is the sixth most common cancer in Iran, with a particularly high incidence in East Azerbaijan. This study aims to compare the survival rates of early-onset esophageal cancer (EOEC) with those of advanced esophageal cancer in this region.
Methods:
A retrospective analysis was conducted on the clinicopathologic and survival data of 532 esophageal cancer (EC) patients who underwent chemoradiotherapy between February 2006 and March 2011 at the Radiation Therapy Center, a provincial cancer center dedicated to treating cancers in a high-incidence area. All patients were native residents of the high-incidence area in northwest Iran. Survival rates were estimated using the life table method, and subgroup comparisons were performed using the log-rank test.
Results:
Of the 532 patients, 205 (44.5%) were female, and 255 (55.5%) were male. The mean age at diagnosis was 65.8 ± 12.2 years, ranging from 24 to 90 years. Among them, 53 (10%) had early-onset esophageal cancer, while 406 (90%) had older-onset esophageal cancer. The 1-, 3-, and 5-year survival rates for patients with early-onset esophageal cancer were 88%, 73%, and 52%, respectively. In contrast, the corresponding survival rates for patients aged 50 years or older were 80%, 47%, and 1%, respectively (P > 0.05) (Figure 1).
Conclusion:
The findings indicate that the diagnosis of esophageal cancer at an early age does not significantly affect survival outcomes compared to older-onset esophageal cancer. |