چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهزاد منصوری | اول |
| جواد محمودی | دوم |
| سید زانیار اطهری | سوم |
| سعید صدیق اعتقاد | چهارم |
| فرشته فرج دخت | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Coenzyme Q10,Vitamin E,HPA Axis |
| خلاصه مقاله | Heat stress, recognized as a significant environmental stressor, can disrupt thermoregulation and provoke neuroinflammation, which in turn may lead to anxiety by altering brain physiology and functional connectivity. This investigation aimed to assess the effects of coenzyme Q10 (Q10) and vitamin E (Vit E), both individually and in combination, on anxiety symptoms induced by heat stress in male mice. The study involved five groups of 12 mice each: a control group, a heat stress group (NS), and three treatment groups receiving either Q10, Vit E, or a combination of both (Q10+Vit E). Mice were exposed to a temperature of 43°C for 15 minutes daily over 14 consecutive days, followed by treatments with normal saline, Q10 (500 mg/kg), Vit E (250 mg/kg), or the combination via gastric administration. After evaluating anxiety-related behaviors, the mice were euthanized for serum corticosterone level measurement and hsp70 gene expression analysis in the prefrontal cortex (PFC). The findings indicated that both Vit E and Q10 treatments, whether administered separately or together, exhibited anxiolytic properties in the heat-stressed subjects. Furthermore, these treatments significantly reduced serum corticosterone levels and decreased hsp70 mRNA expression in the PFC. It is hypothesized that Q10 and Vit E may mitigate anxiety responses associated with heat stress by modulating the hypothalamus-pituitary-adrenal axis. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| New Microsoft Word Document.pdf | 1404/02/22 | 119125 | دانلود |
| oral presentation.pdf | 1403/10/27 | 195378 | دانلود |
