| خلاصه مقاله | Background and aims: Studies suggest a significant role for diet therapy in the management of multiple sclerosis (MS). The Mediterranean-style diet is a plant-based, anti-inflammatory diet with increased fiber consumption, lower intakes of saturated fatty acids, and a high intake of olive oil, as the traditional symbol of this diet style. This systematic review aims to evaluate the effect of adherence to the Mediterranean diet on the outcomes of MS patients.
Methods: Following the PRISMA statement, a systematic search was conducted through PubMed (MEDLINE), Web of Science, Scopus, and Embase online databases and studies concerning the effects of a Mediterranean-like diet on MS patients, or the association between Mediterranean-like diet adherence with MS-related outcomes were included. The risk of bias was assessed using Cochrane RoB2 and JBI's critical appraisal tools.
Results: Out of 348 identified records, 162 records were screened in the title/abstract stage and finally, 14 reports of 12 studies were included (Figure 1). Three RCTs (5 reports) assessed the effects of a Mediterranean-like diet on MS patients and suggested a considerable efficacy for fatigue, cognitive outcomes, and quality of life. Nine observation studies reported an association between audience to Mediterranean-like diet and reduced fatigue and disability among MS patients. Nine observational studies, reported an association between adherence to Mediterranean-style diets and reduced fatigue, severity of the disease, and cognitive functions.
Conclusions: The recommendation for a Mediterranean-style diet may be beneficial in MS patients; however, considering the limitations of the evidence such as the high risk of bias studies, and the limited number of RCTs, there is a necessity for future studies in this matter. |