چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مرتضی عبدی قزلجه | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Stem Cell Therapy, Ischemic Stroke, Neurovascular Repair, Regenerative Medicine |
| خلاصه مقاله | Ischemic stroke, characterized by the interruption of blood flow to the brain, leads to significant neuronal loss and functional impairment. Traditional therapeutic approaches, such as thrombolysis and mechanical thrombectomy, often have limited efficacy, particularly in the context of extensive neuronal damage. In recent years, stem cell therapies have emerged as a promising avenue for neurovascular repair and functional recovery following ischemic stroke. Stem cells possess the unique ability to differentiate into various cell types, including neurons, astrocytes, and endothelial cells, which are essential for the regeneration of damaged neural tissue. Several types of stem cells have been investigated for their potential to promote recovery after ischemic stroke, including mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). These stem cells can modulate inflammatory responses, promote angiogenesis, and enhance neuronal survival, thereby mitigating the detrimental effects of ischemic injury. Experimental studies have demonstrated that stem cell transplantation can improve functional outcomes in animal models of ischemic stroke. Mechanistically, stem cells exert their effects through a variety of pathways, including the release of neurotrophic factors, which support neuronal growth and survival, and the promotion of endogenous repair mechanisms. Furthermore, stem cells can also facilitate the formation of new blood vessels, a critical aspect of neurovascular repair. Clinical trials exploring the safety and efficacy of stem cell therapies for ischemic stroke are currently underway. Early results indicate that these therapies are generally well tolerated and may provide meaningful improvements in neurological function and quality of life. However, challenges remain, including optimal cell source selection, delivery methods, and timing of administration. In conclusion, stem cell therapies represent a promising strategy for neurovascular repair following ischemic stroke. Continued research is essential to fully understand the mechanisms underlying their therapeutic effects and to develop standardized protocols for clinical application. With ongoing advancements, stem cell therapies may pave the way for innovative treatments that improve outcomes for patients affected by ischemic stroke. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| govahi 1.pdf | 1403/11/22 | 236878 | دانلود |
| govahi hozor.pdf | 1403/11/22 | 219749 | دانلود |
| Screenshot (31).png | 1403/11/22 | 189790 | دانلود |
| 564.jpg | 1403/11/22 | 1789749 | دانلود |
