چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| کامران جاویدی اقدم | اول |
| اعظم صفری | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract: Behcet’s disease (BD) is a multisystemic inflammatory/autoimmune disease with uncertain pathogenesis that affects many organs in the body. Recently attention to studying the association between aberrant expression of long non-coding RNAs (lncRNAs) and their related target genes either in autoimmune diseases, which could be considered as biomarkers and novel therapeutic agents for these diseases. This research was designed to determine the expression levels of lncRNAs NEAT1 and HOTAIR and their associated target protein-coding genes IL-6 and TNF-α in the peripheral blood of 50 BD patients and their matched HCs. The expression levels of the lncRNAs and protein-coding genes in BD active patients were evaluated by qRT-PCR in comparison with matched HCs. Our study showed increased expression levels of HOTAIR and NEAT1 in patients with BD compared with controls (Expression ratio= 26.73, 59.68 P-value 0.0001 respectively). In addition, expressions of TNF-α and IL6 were up-regulated in patients compared HCs (expression ratio= 20.64, 15.14 P-value0.0001 respectively).based roc cure analysis, HOTAIR, NEAT1, TNF-α, IL-6 had a potential diagnostic. Therefore, the change in the expression levels of lncRNAs and significantly alter the the IL-6 and TNF-α expression level which may serve as a powerful biomarker for prognosis and target therapy for BD disease. |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 22_644_kamran javidi aghdam.jpg | 1403/10/12 | 611126 | دانلود |
| G-1062.pdf | 1403/10/12 | 949924 | دانلود |
