چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | ثمین حمیدی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | روانپزشکی و علوم رفتاری |
| کد مقاله | 86463 |
| عنوان فارسی مقاله | Gel-Based Nanoparticles: Advancing Targeted Drug Delivery for Central Nervous System Disorders |
| عنوان لاتین مقاله | Gel-Based Nanoparticles: Advancing Targeted Drug Delivery for Central Nervous System Disorders |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | سیزدهمین کنگره علوم اعصاب پایه و بالینی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/09/21 الی 1403/09/23 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://bcncongress.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثمین حمیدی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Gel-Based Nanoparticles |
| خلاصه مقاله | Central Nervous System (CNS) disorders represent a significant global health challenge, ranking among the leading causes of disability and morbidity worldwide. Despite substantial advancements in neuropharmacology, the effective management of CNS disorders remains a formidable task, primarily due to the blood-brain barrier (BBB) that severely restricts the access of therapeutic agents to their intended targets in the brain. In response to this persistent challenge, researchers have turned to innovative drug delivery systems, with a particular emphasis on gel-based nanoparticles (NPs). This review explores the cutting-edge developments in gel-based NP formulations and their potential to revolutionize the treatment of CNS disorders. Our methodology involved a comprehensive analysis of recent literature, focusing on studies investigating the application of gel-based nanoparticles in CNS drug delivery. We conducted an extensive search across major scientific databases, including PubMed, Web of Science, and ScienceDirect, using keywords such as 'gel-based nanoparticles,' 'CNS drug delivery,' and 'neurological disorders.' The review process entailed a careful examination of the unique characteristics, fabrication methods, and therapeutic efficacy of various gel-based NP formulations in the context of CNS treatment. The results of our analysis reveal promising advancements in the field of gel-based nanoparticle drug delivery for CNS disorders. These innovative formulations demonstrate several key advantages over traditional drug delivery methods. Firstly, gel-based NPs exhibit an enhanced ability to penetrate the BBB, significantly improving the bioavailability of CNS-targeted medications in the brain. The gel matrix provides a protective environment for the encapsulated drugs, shielding them from degradation and premature release. Additionally, these NPs offer the potential for controlled and sustained drug release, allowing for more stable drug concentrations in the brain over extended periods. This characteristic is particularly beneficial for managing chronic neurological conditions that require long-term treatment, such as neurodegenerative diseases and epilepsy. Furthermore, the versatility of gel-based NPs allows for the incorporation of multiple therapeutic agents, opening avenues for combination therapies tailored to complex CNS disorders. The studies reviewed also indicate a reduction in systemic side effects, as the targeted nature of these delivery systems minimizes drug exposure to non-target tissues. In conclusion, gel-based nanoparticles represent a promising frontier in targeted drug delivery for CNS disorders. By effectively navigating the BBB and offering controlled release profiles, these innovative formulations have the potential to significantly enhance the efficacy of treatments for a wide range of neurological conditions, including neurodegenerative diseases, stroke, brain tumors, and neuroinfectious diseases. The unique characteristics of gel-based NPs, including their ability to protect and precisely deliver therapeutic agents to the brain, position them as a viable solution to overcome the longstanding challenges in CNS pharmacotherapy. As research in this field continues to evolve, future studies should focus on optimizing gel formulations for specific CNS disorders, exploring their long-term safety profiles, and conducting clinical trials to validate their efficacy in human subjects. The integration of gel-based nanoparticle technology into CNS treatment regimens could mark a significant leap forward in our ability to manage and potentially cure a wide range of neurological disorders, offering new hope to millions of patients worldwide affected by CNS conditions. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Gel based Poster.pdf | 1403/10/12 | 748416 | دانلود |
| gel based.pdf | 1403/10/12 | 253473 | دانلود |
