چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه فرضی | اول |
| سید ابوالقاسم محمدی | دوم |
| ابراهیم سخی نیا | سوم |
| عفت علیزاده | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Circulating miRNAs, DMD, Diagnosis |
| خلاصه مقاله | Introduction DMD is a member of neuromuscular disorders. This group include similar disease which are hard to distinguish between them. In order to choose the best treatment to administer exact diagnose is necessary. Conventional methods are like CK measurement, EMG evaluation, muscle biopsy, PCR, MLPA, southern blotting, immunohistochemical-based diagnose and NGS-based diagnose. Although these methods are beneficial but disadvantages like being invasive, expensive, non-specific and needing high technology are existing when utilizing them. Recent evidence shows that circulating blood microRNAs evaluation as a specific non-invasive monitoring method may help for DMD diagnosis. The aim of this review is to discuss recent studies about circulating microRNAs as potential biomarkers for detection of DMD. Method All original articles regarding MRNA, exosomes, and cancer treatments were collected, and main findings were summarized in this work. Result Most of the studies in DMD detection area had a similar point of view regarding impact of mir-133-a/133-b/206/499/208-a/208-b(1). This miR frequently demonstrated dysregulation in DMD patients or carrier persons. Expression of this circulating miRs have been evaluated in several patients with different type of mutation in various subgroup of MD. They demonstrated that combined measurement of several miRs not only can be used as diagnostic tool but also may could distinguish in similar cases like DMD and Beker muscular dystrophy (2). The serum levels of miR-95 and miR-539 assessed and reported to become dysregulated in a small cohort study on dogs and human (3). Other microRNAs which were mentioned in previous studies (miR-339-5p/486/1/483/30c/181-a/378) indicate either positive or negative relation with DMD (REF). Conclusion: According to our evaluation, we can confirm that circulating miRNAs, in particular conserved miRNAs could serve as best biomarkers for DMD diagnosing. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IMG_1229.jpeg | 1403/10/08 | 1514321 | دانلود |
| IMG_1228.jpeg | 1403/10/08 | 1947626 | دانلود |
| FF-EA Bio2.pdf | 1403/10/09 | 738210 | دانلود |
