چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه فرضی | اول |
| سید ابوالقاسم محمدی | دوم |
| ابراهیم سخی نیا | سوم |
| آسیه جبلی | چهارم |
| عفت علیزاده | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Cancer therapy by exosomes mediated mRNA delivery Exosomes, a subgroup of secretome, secreted from all cells and play a postman role in and out of the cells by transferring nucleic acid, proteins, lipids, amino acid and other metabolites as a cargo even to distant cells and alter their biological response intrinsically. This aptitude of exosomes changes them as a therapeutic tool for many diseases. Although cancer is the hottest field in treatment study, but unfortunately, there is no ideal therapeutic effects. In this position, exosomes can optimize therapeutic strategies due to having a series of useful properties. Despite the existence of many studies based on the ability to transfer multiple cargoes by exosomes, studies based on the transfer of mRNA by exosomes are very rare. Messenger RNA (mRNA)-based therapeutics involves the delivery of in vitro-transcribed mRNA into the cytoplasm of a target cell, where it is translated into the desired protein and solve the problem of its absence. In this situation, exosomes optimize their transmission. |
| کلمات کلیدی | Cancer, exosomes, mRNA, Messenger RNA |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IMG_1231.jpeg | 1403/10/08 | 2440550 | دانلود |
| EA-FF.pdf | 1403/10/09 | 564486 | دانلود |
