چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کمال کاظمی | اول |
| عفت علیزاده | سوم |
| معصومه امانی دولاما | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: One of the major hallmark of gastric cancer (GC) cells is rapid growing and uncontrolled proliferation, which requires high amount of energy. Consequently, GC cells must alter their metabolic process from oxidative phosphorylation to aerobic glycolysis to could satisfy the energy for sustaining the rapid proliferation (1) . This phenomenon of changes in tumor cellular metabolism, is known as “metabolic reprogramming”, which is mediated by higher uptake of glucose, enhanced expression of glycolysis related enzymes such as HK-II, PKM2 and conversion of pyruvate to lactic acid (2). Emerging evidence reports that miRNAs, as a class of non-coding RNAs are able to target and bind to the 3′-untranslated region (UTR) located on mRNA of enzymes involved in metabolic processes and glucose transporters and inhibit their expression. Therefore, microRNAs can act as important regulators of metabolic reprogramming in GC cells and suppress their growth, invasion and metastasis (3). Based on these characteristics, in the present study, we reviewed the inhibitory role of miRNAs in the alteration of GC cells metabolic reprogramming. Methods: In the present study, we do comprehensive literature review and gathered the results of related articles published between 2022 and 2023 from PubMed and google scholar databases with key words such “gastric cancer”, “glycolysis”, “metabolic reprogramming” AND “microRNA” queries. Results: In the present study, we summarized the role of some microRNAs in the regulation of glycolytic metabolism of GC. We observed that these microRNAs are able to directly or indirectly target the expression of glycolytic genes. For example, MicroRNA-181b (4), MiR‐5683 (5), miR‑449c (6), MiR-let-7a (7) and miR‐148b (8) downregulate the expression hexokinase II, pyruvate dehydrogenase kinase 4, PFKFB3, PKM2 and SLC2A1 in GC, respectively. Subsequently downregulation of these glycolytic metabolism relate enzyme expression, can reduce the glucose uptake and consumption, lactate production, cellular ATP levels and lead to the proliferation and growth suppression in GC cells. Therefore, miRNAs have key duty as very important regulators of glucose metabolism. Conclusion: Understanding the function of microRNAs in the in reprogramming the glycolytic metabolism pathway in GC provides novel insights into the potential therapeutic strategies in GC patients. |
| کلمات کلیدی | microRNAs, metabolic reprogramming, glycolysis, gastric cancer |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ghavahi.jpg | 1403/10/06 | 1210076 | دانلود |
| biomedicine.abstract.docx | 1403/10/09 | 20227 | دانلود |
| abstract.biomedicne.pdf | 1403/10/09 | 239252 | دانلود |
