چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثمین حمیدی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: The blood-brain barrier (BBB) poses a significant challenge in delivering psychiatric medications effectively to the central nervous system. Intranasal drug delivery using nanocarriers offers a promising non-invasive route to bypass this barrier. Aim: To review current advances in nanocarrier-based intranasal delivery systems for psychiatric medications, focusing on BBB penetration enhancement and therapeutic efficacy. Methods: A systematic review was performed using Web of Science, PubMed, and Scopus databases (2015-2024). Studies involving nanocarrier formulations for intranasal delivery of psychiatric drugs were evaluated. Results: Nanocarrier systems including polymeric nanoparticles, lipid-based carriers, and dendrimers demonstrated 2-4 fold higher brain bioavailability compared to conventional formulations. Direct nose-to-brain transport increased drug concentration in target regions by 60-80%. Novel surface modifications improved mucosal adhesion and cellular uptake by 40-50%. Conclusion: Nanocarrier-based intranasal delivery shows significant potential for improving psychiatric drug efficacy. Key advantages include enhanced BBB penetration, targeted delivery, and reduced systemic side effects. Further clinical trials are needed to validate safety and therapeutic outcomes. |
| کلمات کلیدی | nanocarriers, intranasal delivery, blood-brain barrier, psychiatric disorders, drug targeting |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Biomedicine nano.jpeg | 1403/10/05 | 1215275 | دانلود |
| Abstarct biomedicine nano.docx | 1403/10/05 | 13060 | دانلود |
