چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | رسا بهشتی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 86317 |
| عنوان فارسی مقاله | اثر داروهای مهارکننده TLR4 در کاهش حجم ناحیه سکته مغزی و عملکرد عصبی در مدلهای استروک ایسکمیک جوندگان: مطالعه مروری نظام مند |
| عنوان لاتین مقاله | THE EFFECT OF TLR4 INHIBITOR AGENTS ON SIZE OF INFARCTION VOLUME AND NEUROLOGICAL FUNCTIONS IN THE RODENT ISCHEMIC STROKE MODELS: A SYSTEMATIC REVIEW |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 16th World Stroke Congress 23 – 26 October 2024 | ABU DHABI, UAE |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | United Arab Emirates |
| شهر محل برگزاری کنگره/ همایش | Abu Dhabi |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/08/02 الی 1403/08/05 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://journals.sagepub.com/doi/epub/10.1177/17474930241274956 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رسا بهشتی | اول |
| محمد عباسعلیزاده | دوم |
| امیرحسین بهرامی | سوم |
| سعید صدیق اعتقاد | چهارم |
| هانیه صالحی پورمهر | پنجم |
| مهدی فرهودی | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | TLR4 inhibitors, Ischemic stroke, Systematic Review |
| خلاصه مقاله | Background and Aims: Following the reperfusion after cerebral ischemia, the release of cellular stress-related particles known as DamageAssociated Molecular Patterns (DAMPs) activates an inflamatory cascade and causes ischemic-reperfusion injury (IRI). Recent studies investigated the key role of Toll-like Receptors (TLRs), particularly TLR4, in the activation of IRI. Various in vivo studies show the impact of various anti-TLR4 agents on minimizing IRI. We aimed to give a comprehensive review of the efficacy and safety of TLR4 inhibitor agents in the animal model studies. Methods: PubMed, Scopus, Web of Sciences, Embase, and the Cochrane Library were systematically searched. The results were screened by two authors independently. In vivo studies that examined direct TLR4 antagonists or agents with the main inhibitory effect on TLR4 expression in the Middle Cerebral Artery Occlusion (MCAO) or Common Carotid Artery Occlusion models were our inclusion criteria. The risk of bias assessment of the included studies was performed using the CAMARADES criteria by two authors independently. Results: After removing duplicate results and screening according to our inclusion criteria, a total of 6 studies were included. Administration of MTS510 as an anti-TLR4 antibody, miR-542-3p as a TLR4 expression inhibitor, ApTLR#4F and ApTLR#4FT as TLR4-blocking DNA aptamers, TAK-242 and Eritoran (E5564) as TLR4 antagonists, and intracerebroventricular injection of Resatorvid as a TLR4-NOX4 signal inhibitor on the MCAO mice model showed a significant reduction in infarction volume and improvement in neurological function. Conclusions: These findings indicate to potential strategies for employing anti-TLR4 agents in various inhibitory categories to cure cerebral ischemic injury along with reperfusion therapy. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract (TLR 4).pdf | 1403/09/23 | 439280 | دانلود |
| WSC 2024 oral presentation (Abu Dhabi).pdf | 1403/09/23 | 234432 | دانلود |
