چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | امیر ولیزاده دیزجیکان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 86289 |
| عنوان فارسی مقاله | Cell therapy using co-treatment mesenchymal stem cells with exosomes obtained from the umbilical cord in infertile women due to Asherman syndrome |
| عنوان لاتین مقاله | Cell therapy using co-treatment mesenchymal stem cells with exosomes obtained from the umbilical cord in infertile women due to Asherman syndrome |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | هجدهمین کنگره ملی و نهمین کنگره بین المللی بیوشیمی و بیولوژی مولکولی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/08/02 الی 1403/08/04 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://abi.tums.ac.ir/index.php/abi/issue/view/9 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر ولیزاده دیزجیکان | اول |
| مهدی یوسفی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Asherman syndrome, Mesenchymal stem cells, Exosomes, Cell therapy |
| خلاصه مقاله | Abstract Background Asherman syndrome (AS), characterized by intrauterine adhesions, is a significant cause of infertility and menstrual irregularities. Traditional treatments have shown limited success, prompting the exploration of regenerative therapies. Aims This study investigates the potential of co-treating mesenchymal stem cells (MSCs) and exosomes derived from umbilical cords (UC) as a novel therapeutic approach for AS-related infertility. Methods Twelve patients with AS were randomly allocated into four groups: (1) single injection of MSCs, (2) two exosome injections, (3) co-treatment with MSCs and exosomes, and (4) phosphate-buffered saline control. Endometrial gene expression, thickness, adhesions, pregnancy, and live birth rates were assessed. Results The co-treatment group exhibited significant upregulation of genes involved in endometrial regeneration (TGF-β1, ADAM15, ADAM17, SMAD3, Integrinβ3) and downregulation of SMAD7. This group also demonstrated the highest mean endometrial thickness, reduced intrauterine adhesions, and the highest pregnancy (66.7%) and live birth rates. No severe adverse events were reported. Conclusion Co-treatment with UC-derived MSCs and exosomes shows promise as a safe and effective therapy for AS-related infertility, with synergistic effects on endometrial regeneration and reproductive outcomes. These findings warrant further investigation in more extensive clinical trials. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| gavahi.pdf | 1403/09/20 | 825064 | دانلود |
| ketabcheh.pdf | 1403/09/20 | 256320 | دانلود |
| sabt.pdf | 1403/09/20 | 62272 | دانلود |
| sherkat.pdf | 1403/09/20 | 2315975 | دانلود |
| lit.pdf | 1403/09/20 | 1331214 | دانلود |
| blit.pdf | 1403/09/20 | 1284844 | دانلود |
