چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالفضل دوست میهن | اول |
| میراحمد مظلومی | سوم |
| رعنا جهانبان اسفهلان | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | delivery system, nucleic acid, RNA, micelle, nanoparticle |
| خلاصه مقاله | Abstract: The effectiveness and duration of nucleic acids clinical applications are hindered by various obstacles and challenges, both inside and outside cells. These barriers significantly impact the action of nucleic acid drugs and must be overcome. The extensive use of viral vectors for delivering nucleic acids is constrained by various unavoidable challenges. There is an increasing demand for a safe, effective, precise, and non-pathogenic method to deliver gene therapy materials. Remarkably, the integration of gene therapies with nanoscale delivery systems has expanded the range of therapeutic and biomedical uses for these molecules, including applications in bioanalysis, gene inhibition, protein substitution, and vaccine development. Nanomaterials designed for nucleic acid delivery present a unique chance to address these limitations. Gene delivery can be accomplished through chemical carriers that bind the nucleic acid cargo and aid in its uptake and delivery into cells. While these carriers come in a wide range of chemical compositions, they are typically classified as inorganic, peptide, lipid, or polymer-based systems. Polymeric micelles possess key characteristics that can facilitate the effective translation of RNA-based therapeutics to clinical use. These attributes include self-assembly, micellization capability, biocompatibility, thermodynamic stability, substantial exclusion volume, efficient condensation and safeguarding of RNA, minimal toxicity, affinity for biological membranes (enhancing cell interaction and gene transfection), and enhancement of intracellular trafficking through endosomal escape mechanisms. Here, we review the most recent efforts to carry a variety of nucleic acids with micelles. Method: A search was conducted on Google Scholar using the keywords ' nano, micelles and nucleic acid delivery to identify recent studies with noteworthy findings for selection. Results: Recent advancements in utilizing micellar carriers for nucleic acid transport have led to improved target delivery, enhanced uptake, prolonged circulation in the bloodstream, increased gene silencing efficacy, improved cellular absorption, enhanced stability in serum, improved penetration into tumor cells, elevated transfection levels, potential for combined delivery of DNA and anti-cancer drugs in combination therapy, minimal cytotoxicity in vitro, and efficient protection of nucleic acids from enzymatic degradation. Conclusion: Despite significant progress in enhancing nucleic acid-based therapies by reducing immune stimulation, minimizing off-target effects, and enhancing the potency and stability of RNA silencing, addressing delivery challenges remains crucial to validate nucleic acid molecules as potential therapeutic targets or drugs. Therefore, there is an urgent need to develop a highly adaptable delivery system. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IMG_20241207_225520_049.jpg | 1403/09/19 | 590110 | دانلود |
| Abolfazl Doustmihan.docx | 1403/09/19 | 15730 | دانلود |
| Congress Ebook.xlsx | 1403/09/21 | 419233 | دانلود |
