چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کمال کاظمی | اول |
| عفت علیزاده | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Colorectal cancer (CRC), Cancer associated fibroblast (CAF), ncRNA, Exosome |
| خلاصه مقاله | Introduction: Colorectal cancer (CRC) is known to be the most leading cause of cancer related deaths between the women and men. CRC development and progression is basically affected by tumor microenvironment (TME), which is composed of different tumor stroma cells. Cancer associated fibroblasts (CAFs), as one of the most active component of TME, can interact with CRC cells to facilitate their tumorigenesis and development. Emerging evidences reported that communication between the CAFs and CRC cells is mediated with secretion of exosomes. Exosomes are extracellular vesicle (EVs) with small sizes (40 ~ 100 nm) contain proteins, lipids, DNA and ncRNAs (such as lncRNAs, circular RNAs, miRNAs). The ncRNAs carrying exosomes can be secreted from CAFs as a potential intracellular communication mediators and participate in the cell proliferation, growth, survival, metastasis, drug resistance, and immune response of recipient tumor cells through underlying the different molecular mechanisms. In the present study, we aimed to go through the major role of exosomal ncRNAs in CAFs and CRC cells interaction in TME and exploring their molecular mechanisms of action in tumorigenesis. Methods: In this study, we retrieved the results of related articles published between 2020 and 2024 using key words such “colorectal cancer”, “exosome”, “cancer associated fibroblast” AND “ncRNA” queries from reputable databases. Information from these articles was collected and analyzed in this review. Results: Recent studies revealed the critical role of exosomal ncRNAs released from CAF on the malignly behavior of colorectal cancer. These studies reported that CAF-derived exosomal ncRNAs for example, miR-135b-5p (1), miR-93-5p (2), LINC00355 (3), micro-RNA-200b-3p (4), LINC00659 (5), circEIF3K (6) are able to affect the molecular pathways, therefore can induce the cell proliferation, growth, migration, invasion, metastasis and drug resistance in CRC cells. Conclusion: Accumulating evidences demonstrated that exosomes bearing ncRNAs are implicated in the intracellular communication between CAFs and CRC cells in the TME and can play pivotal role in CRC progression through underlying different molecular mechanisms. Therefore, CAFs-derived exosomal ncRNAs can be employed as potential therapeutic targets for CRC treatment. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate1.jpg | 1403/09/12 | 1869363 | دانلود |
| certificate2.jpg | 1403/09/12 | 3615154 | دانلود |
| abstract. genomics.pdf | 1403/10/09 | 258055 | دانلود |
| abstract.genomics (1).docx | 1403/10/09 | 16152 | دانلود |
