| نویسنده ثبت کننده مقاله | فهمیده بگرضایی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 86172 |
| عنوان فارسی مقاله | بررسی میزان دریافت چربی در بیماران مبتلا به سرطان کولورکتال متاستاتیک با جهش KRAS وضعیت: مطالعه مورد شاهدی |
| عنوان لاتین مقاله | Assessment of dietary fat intake in metastatic colorectal cancer patients with KRAS mutation status: A case-control study |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | پنجمین همایش بین المللی تغذیه بالینی ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/07/25 الی 1403/07/27 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.icncongress.ir/fa/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Fahmideh Bagrezaei, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| فهمیده بگرضایی | اول |
| محمد علی زاده | دوم |
| بهرام پورقاسم گرگری | سوم |
| رضا اقدام ضمیری | چهارم |
| ثریا خیروری | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: Fat intake, KRAS mutation status, mCRC |
| خلاصه مقاله | Abstract Introduction: Epidemiological data supports a connection between dietary factors and the KRAS mutation (Kirsten rat sarcoma virus) that contributes to the development of colorectal cancer. This study aims to investigate the relationship between dietary fat intake and metastatic colorectal cancer (mCRC) patients with KRAS mutation status. Methods: This hospital-based case-control study involved 90 patients (45 with wild-type mutations and 45 with mutant mutations) from October 2023 to May 2024. The analysis of KRAS gene mutations was conducted using the Real-Time PCR apparatus with the Easy-KRAS status kit. Dietary intake data were collected from participants using a validated food frequency questionnaire (FFQ) consisting of 147 items. The difference in average fat intake between groups was assessed through multivariate analysis. Results: A statistically significant difference in average trans fat intake was observed between the groups. Trans fat intake was significantly higher in the wild-type group [0.0018 (0.004)] compared to the mutant group [0.0004 (0.0007)]. Conclusions: The study revealed that patients in the mutant group had lower trans fat intake. These findings suggest that reducing trans fat consumption may be linked to a decreased likelihood of genetic mutations in patients with metastatic colorectal cancer. Therefore, monitoring the types of fats consumed in the diets of these patients can have a positive impact on disease management and treatment outcomes. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Fish congre.jpg | 1403/10/22 | 78233 | دانلود |
| Screenshot 2025-02-05 104853.png | 1403/11/17 | 181960 | دانلود |
| ICN5poster.pdf | 1403/09/09 | 536557 | دانلود |