چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کمال کاظمی | اول |
| عفت علیزاده | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Mesenchymal stem cells, Exosomes, M2 macrophage repolarization, Wound healing |
| خلاصه مقاله | Mesenchymal stem cell-derived exosomes and their effects on M2 macrophage polarization and wound healing Introduction: Multiple complex stages are involved in wound healing to repair the damaged tissue. Macrophages as heterogeneous cells play a pivotal and significant role in the different stages of wound healing. Two types of phenotypes of macrophages exist, M1 macrophage (pro-inflammatory) and M2 macrophage (anti-inflammatory). M1 macrophage activation will exert inflammation responses and prevent the wound-healing process, in contrast, M2 macrophage activation eliminates inflammation and promotes tissue repair and wound healing. Exosome, as a nano-scale extracellular vesicle can induce the M2 macrophage polarization from M1 macrophage, reduce inflammation, and improve wound healing. Increasing evidence has shown that exosomes secreted by mesenchymal stem cells (MSCs) can facilitate the M2 macrophage polarization during wound repair and might be a therapeutic target. In the present study, we reviewed the effects of MSCs-derived exosomes on wound healing with particular focus on macrophage repolarization. Methods: In this study, the keywords “mesenchymal stem cell”, “exosome”, “M2 macrophage”, and “wound healing” were searched in reliable databases such as PubMed and Google Scholar between 2018 and 2024, and relevant articles were obtained and analyzed. Result: MSCs-derived exosomes increased the rate of M2 macrophage polarization and induced wound healing by preventing inflammation. In addition, it is demonstrated that MSC-derived exosomes significantly suppressed the pro-inflammatory factors CD86, iNOS, IL-1β, and TNF-α, while increasing the anti-inflammatory factor IL-10 and CD206. Because inflammation is one of the major mechanisms for delaying the wound healing process, considering mentioned outcomes, MSC-derived exosomes can be a potential therapeutic agent for wound healing. Conclusion: These findings proved that MSCs-derived exosomes could accelerate wound healing by eliciting M2 macrophage polarization. Therefore, exosomes might be an effective and innovative treatment for wound healing. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| abstract.tarmim.docx | 1403/09/07 | 13244 | دانلود |
| Cerificate.jpg | 1403/09/17 | 957361 | دانلود |
| Slide1.JPG | 1403/09/27 | 299260 | دانلود |
