چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| اسرا سادات طالبی زنوزی | اول |
| پریناز محنتی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Background: Individual dosimetry makes Yttrium-90(90Y) Transarterial Radioembolization (TARE) safer and more effective. Cherenkov Luminescence Imaging (CLI) has been employed as a novel approach for 90Y imaging. While this technique is straightforward and effectively tackles specific limitations in current nuclear medicine systems, its broad application is hindered by its constrained penetration range and low light yield. The predominant wavelength of Cherenkov radiation falls within the ultraviolet spectrum. As a result, it is strongly absorbed by the medium. The intensity of generated Cherenkov radiation is directly dependent on the refractive index of the medium. Introducing nanoparticles (NPs) with a high refractive index into the medium makes it possible to increase the penetration depth and the number of Cherenkov radiation. Objective: This study aimed to overcome limitations in CLI by utilizing TiO2 NPs during the 90Y TARE. Material & Methods: The simulation of CLI was performed using the Monte Carlo codes GATE (version 9) and GEANT4 (version 10.6). TiO2 NPs (with a diameter of 100 nm) were modeled to be randomly distributed within 90Y-loaded glass microspheres at concentrations of 0, 1.2 mol/L, 2.4 mol/L, and 4.8 mol/L. The Cerenkov radiation spectra emitted from the glass microsphere were computed using GEANT4. The obtained spectra were uniformly distributed within the liver tumor of the MOBY mouse phantom. Subsequently, Cherenkov luminescence images of the tumor were captured using GATE. The dosimetry accuracy was assessed by determining the Root Mean Square Errors (RMSEs) in Cherenkov luminescence image-based Dose Volume Histograms (DVHs) and the reference DVHs. Results: The in-silico results showed that RMSE values decreased significantly as the TiO2 NP concentration increased in the glass microspheres. The maximum RMSE reduction was observed at the TiO2 NP concentration of 4.8 M (17%). Conclusion: Our investigation has provided evidence that integrating TiO2 NPs into the glass microspheres enhances the precision of individual dosimetry in Y-90-TARE. |
| کلمات کلیدی | Transarterial Radioembolization, Dosimetry, Nanoparticle, CLI |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2.pdf | 1403/09/03 | 431892 | دانلود |
| 1.pdf | 1403/09/03 | 96720 | دانلود |
