چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا غلامی سلطان احمدی | اول |
| مرتضی اکبری | دوم |
| عفت علیزاده | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract: With the progress and development of RNA therapy in the last decade, attention was drawn to a special group of noncoding-RNAs called circular RNAs (circRNAs). They are single-stranded molecules characterized by covalently closed structure without 3´ and 5´ ends. High-throughput RNA sequencing identified that they are endogenously expressed in eukaryotes and evolutionarily conserved. Enrichment of circRNAs as well as their tissue and cell-specific expression pattern indicated their various regulatory functions in physiological processes. The aim of this review is to discuss circular RNAs properties and applications in oncotherapy. Method & Materials: All articles published since 2010 were retrieved using keywords “circRNAs” and “cancer treatment” from common databases including PubMed, Google Scholar, and Scopus. The circRNAs characteristics and their cancer therapy related applications were examined thoroughly Result & Conclusion: Biological functions of circRNAs, include the miRNA or RBP sponge, scaffolds for protein interactions, guiding proteins to specific loci or intracellular compartments, and protein-coding circRNAs with an intrinsic IRES element. The circular structure of these RNAs makes them resistant to the exonucleases, leading to increased half-life in biological environments. The accumulation of circRNAs inside the cell makes them suitable candidates not only as therapeutic targets (e.g., sponging miR-9 in syngeneic breast cancer mouse model) but also as diagnostic and prognostic biomarkers in many cancer types. Also, researchers have designed and investigated the effects of artificial circRNAs for cancer treatment, diagnosis, and prognosis. By the expanding of circRNAs related knowledge, this bio-tool will have great potential to translate in to oncology clinics in the future |
| کلمات کلیدی | Circular RNA, non-coding RNA, miRNA sponge, Cancer therapy |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 22_651_Sarah gholami.jpg | 1403/08/29 | 590198 | دانلود |
| G-1361 (1).pdf | 1403/08/29 | 912259 | دانلود |
