چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| رضا نعمت الهی ملکی | اول |
| مژگان لطفی | چهارم |
| اکرم قهرمانیان | دوم |
| حامد قلیزاد گوگجه یاران | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: Alzheimer Disease; Amyloid-Beta Peptides; Intracerebral Hemorrhage; Clusterin; Family caregivers; Genetic Predisposition to Disease; Intracerebral hemorrhage; PICALM protein, human; Receptors, Complement; Risk factors |
| خلاصه مقاله | Abstract Background: Evidence suggests that Alzheimer's disease (AD) may act as one of the contributing factors in the development of intracerebral hemorrhage (ICH), indicated by increased incidence of ICH in patients with AD. This kind of genetic-based understanding of factors like CR1, CLU, and PICALM may enable the caregiver to anticipate risks and adopt precautionary measures to overcome them. While CR1 mediates immune response and inflammation, CLU and PICALM are associated with amyloid-beta metabolism and endocytosis, respectively. Objective: This review systematically reviewed the genetic underpinnings and shared pathophysiology between AD and ICH, focusing on the involvement of CR1, CLU, and PICALM genes. It also put forward some practical proposals on how to prevent ICH from occurring among AD patients as proposed by family caregivers. Methods: A comprehensive search of the literature has been run on several databases such as PubMed, Google Scholar, and Scopus, using keywords related to AD, intracerebral hemorrhage, and genes mentioned. The inclusion criteria limit the studies to those providing empirical data with regard to genetic associations and the mechanisms that connect AD and intracerebral hemorrhage. Results: In this systematic review, the genetic links between AD and ICH were elaborated, and it was found that CR1, CLU, and PICALM genes are associated with Alzheimer's disease. The CR1 gene contributes to susceptibility to both Alzheimer's disease and intracerebral hemorrhage through immune modulation and vascular integrity. Expression of CLU impacts amyloid-β clearance and thus plays an important role in AD pathogenesis and, possibly, in amyloid-β metabolism in ICH. PICALM is involved in the processing of APP and in blood-brain barrier integrity, thus participating in the pathophysiology of both diseases. CAA would appear to be a point of conjunction, since amyloid-β deposits would seem to be the link between the pathophysiology of AD and ICH. These findings point toward mechanisms that are common in both AD and ICH. Conclusion: This systematic review has highlighted the interaction of AD, intracerebral hemorrhage, and variations of CR1, CLU, and PICALM. The findings indicate that increased awareness should be developed with the implementation of specific preventive strategies against ICH in patients diagnosed with AD. Family caregivers should be given educational guidelines on the management of shared risk factors to give further support to their loved ones. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate of Presentation.pdf | 1403/10/16 | 219110 | دانلود |
| stroke congress.png | 1403/08/17 | 532243 | دانلود |
