فناوری‌های نوآورانه برای درمان زخم‌های مزمن: بررسی نقش راهبردهای مبتنی بر نانو‌درمان ها

innovative technologies for chronic wound healing: exploring the role of nanotherapeutics based strategies


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نویسندگان: مریم قهرمانی نسب , عزیزه رحمانی دل بخشایش , حامد ولی زاده , دیبا قاسمی , ابوالفضل برزگری , سید محمد باقر پیروز پناه

عنوان کنگره / همایش: یازدهمین کنگره بین المللی زخم و ترمیم بافت , , تهران , 2024

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نویسنده ثبت کننده مقاله دیبا قاسمی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه مرکز جامع سلولهای بنیادی و پزشکی بازساختی SCARM
کد مقاله 85910
عنوان فارسی مقاله فناوری‌های نوآورانه برای درمان زخم‌های مزمن: بررسی نقش راهبردهای مبتنی بر نانو‌درمان ها
عنوان لاتین مقاله innovative technologies for chronic wound healing: exploring the role of nanotherapeutics based strategies
نوع ارائه پوستر
عنوان کنگره / همایش یازدهمین کنگره بین المللی زخم و ترمیم بافت
نوع کنگره / همایش بین المللی
کشور محل برگزاری کنگره/ همایش
شهر محل برگزاری کنگره/ همایش تهران
سال انتشار/ ارائه شمسی 1403
سال انتشار/ارائه میلادی 2024
تاریخ شمسی شروع و خاتمه کنگره/همایش 1403/08/30 الی 1403/09/02
آدرس لینک مقاله/ همایش در شبکه اینترنت https://www.wtrc.ir/fa/
آدرس علمی (Affiliation) نویسنده متقاضی Stem Cells and Regenerative Medicine Innovation Center, Tabriz University of Medical Sciences, Tabriz, Iran

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نویسنده نفر چندم مقاله
مریم قهرمانی نسباول
عزیزه رحمانی دل بخشایشدوم
حامد ولی زادهسوم
دیبا قاسمیچهارم
ابوالفضل برزگریپنجم
سید محمد باقر پیروز پناهششم

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عنوان متن
کلمات کلیدیWound Healing, Nanotherapeutic, 3D Bioprinting, Stem Cell Therapy
خلاصه مقالهWound healing is a complex and dynamic process essential for the repair of injured tissue. Incomplete or improper healing can lead to abnormal scar formation and chronic wounds, which increase susceptibility to infections and negatively impact patients' quality of life. Chronic wounds also impose significant financial burdens on healthcare systems worldwide. Effective management of these wounds necessitates specialized biomedical treatments due to the intricate nature of the healing process and the need for long-term care. Current therapeutic options, including skin grafts, wound dressings, growth factor delivery, gene therapy, and cell therapy, vary in effectiveness based on wound type, highlighting the limitations of existing approaches. To address these challenges, there is an urgent need for innovative therapeutic methods that can treat a broader range of wounds effectively. Recent advancements in wound care technologies, such as nanotherapeutics, bioengineered skin grafts, 3D bioprinting, and stem cell therapy, are being explored to enhance skin regeneration with minimal side effects, thus improving outcomes for chronic wound management [1]. Nanotherapeutic strategies have emerged as effective methods for enhancing wound healing through the use of various nanomaterials, such as nanoparticles and nanofibers, loaded with antimicrobial agents and therapeutic agents. These approaches address challenges associated with traditional wound healing, such as infection, poor penetration, and delayed healing. The rapid advancement of nanotechnology has enables improved drug delivery through nanoparticulate systems, which providing sustained release and enhanced bioavailability while reducing the frequency of administration [1]. The small size of nanocarriers facilitates intracellular delivery, maintains a moist environment, and ensures stability. Nanotherapies improve microbial infection management in chronic wounds through enhanced drug delivery and interactions, offering significant advantages over conventional methods. Nanomaterials used in chronic wound management can be broadly classified into two major categories, each possessing unique properties and efficacy [2-3]. The first category includes organic nanomaterials, which include solid-lipid nanoparticles, nanosheets, liposomes, micelles, nanoemulsions, nanofibers, and polymeric nanoparticles. The second category consists of inorganic nanomaterials, such as magnetic nanoparticles, carbon nanotubes, quantum dots, and metal nanoparticles. Nanoparticles composed of metals and metal oxides, including gallium, copper oxide, iron oxide, titanium dioxide, aluminum oxide, zinc oxide (ZnO), zinc, and gold, exhibit outstanding antibacterial properties that facilitate the enhancement of wound healing [4-6]. Furthermore, materials such as bioactive glass, nitric oxide (NO) nanoparticles, cerium, and carbon-based nanoparticles, which have inherent bioactivity, have also been used in the management of chronic wounds [7].

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