چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سجادی | اول |
| سیده عاطفه کرمانی | دوم |
| محمد رضا سیاهی شادباد | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: 5- Hydroxy methyl-2- furaldehyde (5-HMF) is one of the major genotoxic contaminant in the maillard reaction, presents in a wide variety of processed foods. It also forms as a decomposition product of glucose, fructose, and saccarose solution formulations, dialysis fluids, and medical syrups containing saccarose and invert syrups which are thermolyzed and subjected to heat sterilization. In experimental animals and model systems the motagenic and DNAStrand-breaking effects of this furaldehyde has been reported. Method: In the present research, controlling and measuring 5-HMF concentration in the injection serums (with dextrose concentrations of 3.33, 5, 10, 20, and 50 present) and some medical colorless syrups (Hydroxyzin, Salbutamol, Calcium and Grip Mixture) with the method of difference spectrophotometric. Results: The licensed concentration of 5-HMF in medical products is 2 µg/ml. The concentration of 5-HMF in the experiment serum was around the license. In the dense serums of dextrose, the amount of 5-HMF was more than diluted serum. An acidic environment and higher heat cause 5-HMF to be produced in sugar- serums. The concentration of 5-HMF in the Hydroxyzin syrups, Salbutamol, and Calcium has been around licensed. But in the Grip Mixture syrup concentration of 5-HMF, 2.484 µg/ml has been a little more than the licensed period. Conclusion: Reformation of production and control of chemical production which holding sugar has great importance. |
| کلمات کلیدی | Dextrose, 5-HMF, Millard reaction |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 5HMF oral.pdf | 1403/08/14 | 395614 | دانلود |
| 5HMF ketabche.pdf | 1403/08/29 | 448868 | دانلود |
